反应条件
1: iPr2NEt / tetrahydrofuran / 1 h / -78 to 0 deg C 2: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 0 deg C 3: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min 4: 99 percent / LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 5: 77 percent / HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 6: 81 percent / iPr2NEt / methanol View Scheme
参考文献
Chen; Beylin; Marlatt; Leja; Goel
Tetrahedron Letters, 1992 , vol. 33, # 23 p. 3293 - 3296
