(R)-(-)-2-辛醇合成路线 （共 140 条）
反应条件
alcohol dehydrogenase from Thermoanaerobium brockii; NADH-specific (R)-selective-ADH; YcnD-oxidoreductase T=30°C; pH=7.5; 6 h; aq. bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantiospecific reaction;
参考文献
Voss, Constance V.; Gruber, Christian C.; Faber, Kurt; Knaus, Tanja; Macheroux, Peter; Kroutil, Wolfgang
Journal of the American Chemical Society, 2008 , vol. 130, # 42 p. 13969 - 13972
反应条件
1: With DMEAD; 4-carboxyphenyldiphenylphosphine in tetrahydrofuran T=20°C; 0.166667 h; 2: With water; sodium hydroxide in tetrahydrofuran T=20°C; stereospecific reaction;
参考文献
Muramoto, Natsuko; Yoshino, Kazuki; Misaki, Tomonori; Sugimura, Takashi
Synthesis (Germany), 2013 , vol. 45, # 7 art. no. SS-2013-F0030-OP, p. 931 - 935
反应条件
methanol; N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide in tetrahydrofuran T=25°C; 2 h;
参考文献
Guindon, Yvan; Ogilvie, William W.; Bordeleau, Josee; Cui, Wei Li; Durkin, Kathy; Gorys, Vida; Juteau, Helene; Lemieux, Rene; Liotta, Dennis; Simoneau, Bruno; Yoakim, Christiane
Journal of the American Chemical Society, 2003 , vol. 125, # 2 p. 428 - 436
反应条件
Novozyme 435 in neat (no solvent) T=45°C; P=760.051 Torr; 16 h; Molecular sieveGreen chemistryEnzymatic reaction; enantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 5-6 p. 249 - 253
反应条件
methanesulfonic acid; (R,R)-dihydroborate in hexane T=-20°C; 48 h; Title compound not separated from byproducts;
参考文献
Imai, Toshiro; Tamura, Tadashi; Yamamuro, Akira; Sato, Tsuneo; Wollmann, Theodor A.; et al.
Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7402 - 7404
反应条件
sodium hydroxide in ethanol; water 1 h; Heating;
参考文献
Jaeger
Synthesis, 1991 , # 6 p. 465 - 469
反应条件
potassium hydroxide in methanol 1 h;
参考文献
Cambou, Bernard; Klibanov, Alexander M.
Journal of the American Chemical Society, 1984 , vol. 106, # 9 p. 2687 - 2692
反应条件
hydrogen; lipase B from Candida antarctica in toluene T=70°C; P=750.075 Torr; 48 h; Resolution of racemateEnzymatic reaction;
参考文献
European Journal of Organic Chemistry, , vol. 2014, # 14 p. 2917 - 2923
反应条件
borane; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Delair, P.; Einhorn, C.; Einhorn, J.; Luche, J. L.
Tetrahedron, 1995 , vol. 51, # 1 p. 165 - 172
反应条件
[(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; bis(acetylacetonate)nickel(II) in tetrahydrofuran; hexane T=-20°C; 6 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 15 p. 2232 - 2234
