反应条件
1: 1.) LDA, 2.) hexamethylphosphoric triamide (HMPT) / 1.) THF, hexane, from -30 deg C to RT, 30 min, 2.) THF, hexane, reflux, 16 h
2: 1N aq. HCl / tetrahydrofuran; methanol / 24 h / Ambient temperature
View Scheme
参考文献
Collins; Dajani; Pappo; Gasiecki; Bianchi; Woods
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 786 - 790
