2,2-二甲基-3-羟基丙醛合成路线 （共 61 条）
反应条件
sodium hydroxide; oxygen; palladium/alumina T=39.85°C; P=760 Torr; Kinetics; Further Variations:Temperatures;
参考文献
Wessely
Monatshefte fuer Chemie, 1900 , vol. 21, p. 220
参考文献
Wessely
Monatshefte fuer Chemie, 1901 , vol. 22, p. 66
反应条件
water; calcium chloride anschliessendes Erwaermen mit Oxalsaeure;
参考文献
Reichstein; Gruessner
Helvetica Chimica Acta, 1940 , vol. 23, p. 653
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Beer; Preobrashenskii
Vitamin Res. News U.S.S.R.Chem.Abstr., 1946 , # 1 p. 43,46
Vitamin Res. News U.S.S.R.Chem.Abstr., 1948 , p. 2579
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Abbott Labor.
Patent: US2305466 , 1944 ;
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Carter; Ney
Journal of the American Chemical Society, 1941 , vol. 63, p. 312
反应条件
water; calcium chloride anschliessendes Erwaermen mit wss. Salzsaeure;
参考文献
Ford
Journal of the American Chemical Society, 1944 , vol. 66, p. 20
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Sikorska; Lewenstein
Acta Poloniae Pharmaceutica, 1959 , vol. 16, p. 425
Chem.Abstr., 1960 , p. 7979
反应条件
Verseifung des Reaktionsprodukts mit Salzsaeure;
参考文献
Glaser
Monatshefte fuer Chemie, 1904 , vol. 25, p. 47
反应条件
1: 1) butyllithium / 1) THF-hexane, -78 deg C, 2 h, 2) THF-hexane, room temp., overnight 2: pyridine / toluene; CH2Cl2 / Ambient temperature 3: 95 percent / HBF4 / tetrahydrofuran; H2O / 2 h / Ambient temperature 4: 51 percent / CsF / tetrahydrofuran / 48 h 5: 87 percent / trimethylsilyl chloride, tetrabutylammonium bromide / acetonitrile / 15 h / 40 °C 6: 56 percent / phosphopantetheine adenylyltransferase, dephosphocoenzyme A kinase, MgCl2, pyrophosphatase, pyruvate kinase, phospho(enol) pyruvate / H2O; various solvent(s) / 168 h / Ambient temperature 7: Crotalus atrox venom nucleotide pyrophosphatase EC 3.6.1.9 / H2O / 4 h 8: potato acid phosphatase EC 3.1.3.2 / H2O / 21 h View Scheme
参考文献
Rama Rao; Mahender Rao; Sharma
Tetrahedron Letters, 1994 , vol. 35, # 31 p. 5735 - 5738
反应条件
sodium methylate; potassium iodide T=17°C; electrooxidation;
参考文献
Okimoto, Mitsuhiro; Chiba, Toshiro
Journal of Organic Chemistry, 1988 , vol. 53, # 1 p. 218 - 219
反应条件
1: With sulfuric acid in water; xylene T=60°C; 14 h; 2: With sodium hydroxide Conversion of starting material;
参考文献
MITSUBISHI GAS CHEMICAL COMPANY, INC.
Patent: EP1598357 A1, 2005 ;
Location in patent: Page/Page column 8 ;
参考文献
Franke; Kohn
Monatshefte fuer Chemie, 1904 , vol. 25, p. 866
参考文献
Franke; Kohn
Monatshefte fuer Chemie, 1906 , vol. 27, p. 1101
