2-氧代戊烷-1,5-二甲酸二乙酯合成路线 （共 51 条）
反应条件
1: With hydrogen; CN; 5percent Pt/Al2O3 in acetic acid T=20°C; Catalytic hydrogenation; P=750.075 Torr; 2: With toluene-4-sulfonic acid in acetic acid Cyclization; Further stages. Title compound not separated from byproducts.;
参考文献
Balazsik, Katalin; Szoeri, Kornel; Felfoeldi, Karoly; Toeroek, Bela; Bartok, Mihaly
Chemical Communications, 2000 , # 7 p. 555 - 556
反应条件
Mucor rouxii freeze-dried yeast-like cells in hexane; water T=28°C; 24 h;
参考文献
Drioli, Sara; Nitti, Patrizia; Pitacco, Giuliana; Tossut, Laura; Valentin, Ennio
Tetrahedron Asymmetry, 1999 , vol. 10, # 14 p. 2713 - 2728
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Cappon, J. J.; Baart, J.; Walle, G. A. M. van der; Raap, J.; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1991 , vol. 110, # 5 p. 158 - 166
反应条件
baker's yeast Ambient temperature;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 14 p. 2713 - 2728
反应条件
1: With hydrogen; CN; 5percent Pt/Al2O3 in acetic acid T=20°C; Catalytic hydrogenation; P=750.075 Torr; 2: With toluene-4-sulfonic acid in acetic acid Cyclization; Further stages. Title compound not separated from byproducts.;
参考文献
Balazsik, Katalin; Szoeri, Kornel; Felfoeldi, Karoly; Toeroek, Bela; Bartok, Mihaly
Chemical Communications, 2000 , # 7 p. 555 - 556
反应条件
Mucor rouxii freeze-dried yeast-like cells in hexane; water T=28°C; 24 h;
参考文献
Drioli, Sara; Nitti, Patrizia; Pitacco, Giuliana; Tossut, Laura; Valentin, Ennio
Tetrahedron Asymmetry, 1999 , vol. 10, # 14 p. 2713 - 2728
反应条件
sulfuric acid; trichlorophosphate in benzene
Heating;
参考文献
Shin; Sato; Honda; Yoshimura
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2652 - 2656
反应条件
1: 57 percent / POCl3, conc. H2SO4 / benzene / Heating
2: 1.) KI / 1.) ethanol, 2.) ethanol, RT, 2 h
3: 60 percent / LiAlH4 / tetrahydrofuran / -10 °C
View Scheme
参考文献
Shin; Sato; Honda; Yoshimura
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2652 - 2656
反应条件
1: 57 percent / POCl3, conc. H2SO4 / benzene / Heating
2: 1.) KI / 1.) ethanol, 2.) ethanol, RT, 2 h
3: 60 percent / LiAlH4 / tetrahydrofuran / -10 °C
4: N-bromosuccinimide (NBS) / CHCl3 / 0.17 h / Ambient temperature
5: H2, Et3N / 10percent Pd/C / methanol / 0.33 h / Ambient temperature
6: 34 percent / H2O, N-bromosuccinimide (NBS) / CHCl3 / 3 h / Ambient temperature
View Scheme
参考文献
Shin; Sato; Honda; Yoshimura
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2652 - 2656
反应条件
1: 57 percent / POCl3, conc. H2SO4 / benzene / Heating
2: 1.) KI / 1.) ethanol, 2.) ethanol, RT, 2 h
3: 60 percent / LiAlH4 / tetrahydrofuran / -10 °C
4: N-bromosuccinimide (NBS) / CHCl3 / 0.17 h / Ambient temperature
5: 64 percent / H2 / 10percentPd/C / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Shin; Sato; Honda; Yoshimura
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2652 - 2656
