3-氨基-2,2-二甲基丙酸乙酯合成路线 （共 5 条）
反应条件
2: NaOH / dioxane View Scheme
参考文献
Fotouhi, Nader; Joshi, Pramod; Fry, David; Cook, Charles; Tilley, Jefferson W.; Kaplan, Gerry; Hanglow, Angela; Rowan, Karen; Schwinge, Virginia; Wolitzky, Barry
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1171 - 1173
反应条件
hydrogenchloride Heating;
参考文献
FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.
Patent: WO2013/134660 A1, 2013 ;
Location in patent: Paragraph 0268 ;
反应条件
ammonia; hydrogen; 5 Rh/Al2O3 in ethanol
T=20°C; 40 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2009/67547 A1, 2009 ;
Location in patent: Page/Page column 207; 208 ;
WO 2009/067547 A1
反应条件
1: 3-bromo-2,2-dimethylpropionic acid With ammonia in water
T=0 - 55°C; 72 h; Sealed high-pressure vessel;
2: ethanol With thionyl chloride
T=0 - 20°C; Heating / reflux;
参考文献
Krepski, Larry R.; Dellaria Jr., Joseph F.; Duffy, Daniel E.; Amos, David T.; Zimmermann, Bernhard M.; Moser, William H.
Patent: US2007/219196 A1, 2007 ;
Location in patent: Page/Page column 51 ;
反应条件
methyl-magnesium iodide; diethyl ether
参考文献
Testa; Fontanella
Justus Liebigs Annalen der Chemie, 1959 , vol. 625, p. 95,97
