3-(4-硝基苯基)-L-丙氨酸盐酸盐合成路线 （共 5 条）
反应条件
1: ethanol With thionyl chloride T=0 - 20°C; 0.75 h; 2: (2S)-2-amino-3-(4-nitrophenyl)-propanoic acid Heating / reflux;
参考文献
MERCK and CO., INC.
Patent: WO2006/115918 A2, 2006 ;
Location in patent: Page/Page column 17 ;
反应条件
thionyl chloride T=0 - 20°C; Heating / reflux;
参考文献
WO2005/87760 A1, ;
Page/Page column 18 ;
反应条件
sodium hydroxide in dichloromethane; water
参考文献
CELLTECH R and D LIMITED
Patent: WO2004/7428 A1, 2004 ;
Location in patent: Page 45 ;
反应条件
triethylamine in dichloromethane
4 h; Ambient temperature;
参考文献
Kupczyk-Subotkowska, Lidia; Siahaan, Teruna J.; Basile, Anthony S.; Friedman, Henry S.; Higgins, Patricia E.; Song, Di; Gallo, James M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1726 - 1730
反应条件
1: 80 percent / triethylamine / CH2Cl2 / 4 h / Ambient temperature
2: 100 percent / H2, ammonium formate / 10percent Pd/C / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Kupczyk-Subotkowska, Lidia; Siahaan, Teruna J.; Basile, Anthony S.; Friedman, Henry S.; Higgins, Patricia E.; Song, Di; Gallo, James M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1726 - 1730
