2-[3-(三氟甲基)苯氧基]乙酸甲酯合成路线 （共 9 条）
反应条件
1: With sodium hydroxide; water in methanol T=20°C; 0.333333 h; 2: With hydrogenchloride in water
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/78291 A1, 2008 ;
Location in patent: Page/Page column 57 ;
WO 2008/078291 A1
反应条件
1: methanephosphonic acid dimethyl ester With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere; 2: methyl 2-[3-(trifluoromethyl)phenoxy]acetate in tetrahydrofuran T=-78 - 20°C; 2.5 h; Inert atmosphere;
参考文献
Mudduluru, Harikrishna; Hindupur, Rama M.; Dubey, Pramod K.; Madhavaram, Shankar; Tatini, Lakshmikumar; Subbaraju, Gottumukkala V.
Letters in Organic Chemistry, 2011 , vol. 8, # 4 p. 234 - 241
反应条件
potassium carbonate in butanone
3 h; Heating / reflux;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/78291 A1, 2008 ;
Location in patent: Page/Page column 57 ;
WO 2008/078291 A1
反应条件
potassium carbonate in acetone
15 h; Reflux;
参考文献
CAYMAN CHEMICAL COMPANY; CHAMBOURNIER, Gilles; KORNILOV, Andriy; MAHMOUD, Hussein, M.; VESELY, Ivan; BARRETT, Stephen, Douglas
Patent: WO2011/46569 A1, 2011 ;
Location in patent: Page/Page column 58-59 ;
反应条件
1: NaOH; water / 100 °C
2: concentrated sulfuric acid
View Scheme
参考文献
Soper et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 2849,2851
参考文献
Soper et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 2849,2851
反应条件
1: 90 percent / i-Bu2AlH / -70 °C
2: 85 percent
View Scheme
参考文献
Danilova, N. A.; Miftakhov, M. S.; Lopp, M. I.; Lille, Yu. E.; Tolstikov, G. A.
Doklady Chemistry, 1983 , vol. 273, p. 375 - 377
Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 273, # 3 p. 620 - 622
反应条件
diisobutylaluminium hydride
T=-70°C;
参考文献
Danilova, N. A.; Miftakhov, M. S.; Lopp, M. I.; Lille, Yu. E.; Tolstikov, G. A.
Doklady Chemistry, 1983 , vol. 273, p. 375 - 377
Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 273, # 3 p. 620 - 622
反应条件
1.1: n-butyllithium / tert-butyl methyl ether; hexanes / 4 h / -75 - -65 °C / Inert atmosphere
1.2: 21 h / -70 - 20 °C / Inert atmosphere
1.3: 0 - 25 °C
2.1: triethylamine; lithium chloride / tetrahydrofuran / 15.5 h / -10 - -5 °C
View Scheme
参考文献
CAYMAN CHEMICAL COMPANY; CHAMBOURNIER, Gilles; KORNILOV, Andriy; MAHMOUD, Hussein, M.; VESELY, Ivan; BARRETT, Stephen, Douglas
Patent: WO2011/46569 A1, 2011 ;
