1-(3-氟-4-羟基苯基)-1-丙酮合成路线 （共 7 条）
反应条件
water; hydrogen bromide
1 h; Reflux;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0168 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate
参考文献
Pfizer Inc.
Patent: US6258827 B1, 2001 ;
US 6258827 B1
Title/Abstract Full Text Show Details
Pfizer Inc.
Patent: US6046213 A1, 2000 ;
反应条件
aluminium trichloride in dichloromethane
参考文献
Pfizer Inc.
Patent: US6258827 B1, 2001 ;
US 6258827 B1
Title/Abstract Full Text Show Details
Pfizer Inc.
Patent: US6046213 A1, 2000 ;
反应条件
AlCl3, aluminium chloride in 1,2-dichloro-benzene
T=100°C; 24 h;
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: WO2006/27236 A1, 2006 ;
Location in patent: Page/Page column 49-51 ;
反应条件
1: tetrahydrofuran; diethyl ether / 0 - 20 °C
2: hydrogen bromide; water / 1 h / |Reflux
View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
1: N,N-dimethyl-formamide / 120 °C
2: tetrahydrofuran; diethyl ether / 0 - 20 °C
3: hydrogen bromide; water / 1 h / |Reflux
View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
1: AlCl3; CS2
2: pyridine hydrochloride
View Scheme
参考文献
Buu-Hoi et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 910,914
