1-苯基-1,4-戊二酮合成路线 （共 177 条）
反应条件
1: benzaldehyde With sodium cyanide in N,N-dimethyl-formamide T=35°C; Stetter reaction; 0.416667 h; 2: methyl vinyl ketone in N,N-dimethyl-formamide T=35°C; Stetter reaction; 2.33333 h;
参考文献
Ryzhkov; Andreev; Belov; Kurkin; Yurovskaya
Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 2 p. 182 - 193
反应条件
hydrogenchloride in tetrahydrofuran; water T=20°C;
参考文献
Barluenga, Jose; Fanlo, Hugo; Lopez, Salome; Florez, Josefa
Angewandte Chemie - International Edition, 2007 , vol. 46, # 22 p. 4136 - 4140
反应条件
water; oxygen; copper diacetate; palladium dichloride in N,N-dimethyl acetamide T=20°C; 48 h;
参考文献
Paradas, Miguel; Campana, Araceli G.; Estevez, Rosa E.; De Cienfuegos, Luis Alvarez; Jimenez, Tania; Robles, Rafael; Cuerva, Juan M.; Oltra, J. Enrique
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3616 - 3619
反应条件
zinc dibromide in tetrahydrofuran T=60°C; Alkylation; 2 h;
参考文献
Yasuda, Makoto; Tsuji, Shoki; Shigeyoshi, Yusuke; Baba, Akio
Journal of the American Chemical Society, 2002 , vol. 124, # 25 p. 7440 - 7447
反应条件
3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; isopropyl alcohol in tetrahydrofuran T=70°C; Sila-Stetter reaction;
参考文献
Mattson, Anita E.; Bharadwaj, Ashwin R.; Zuhl, Andrea M.; Scheidt, Karl A.
Journal of Organic Chemistry, 2006 , vol. 71, # 15 p. 5715 - 5724
反应条件
palladium diacetate; tris(4-methoxyphenyl)-phosphine; trimethylacetic anhydride in tetrahydrofuran; water T=60°C; 16 h;
参考文献
Goossen, Lukas J.; Ghosh, Keya
European Journal of Organic Chemistry, 2002 , # 19 p. 3254 - 3267
反应条件
zinc dibromide in tetrahydrofuran T=40°C; 24 h;
参考文献
Yasuda, Makoto; Tsuji, Shoki; Shigeyoshi, Yusuke; Baba, Akio
Journal of the American Chemical Society, 2002 , vol. 124, # 25 p. 7440 - 7447
反应条件
tributylphosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in acetonitrile 20 h; Heating;
参考文献
Lu, Xiyan; Ji, Jianguo; Ma, Dawei; Shen, Wei
Journal of Organic Chemistry, 1991 , vol. 56, # 20 p. 5774 - 5778
反应条件
AlCl3, aluminium chloride T=25 - 35°C; 2 h;
参考文献
LUPIN LIMITED
Patent: WO2006/109323 A1, 2006 ;
Location in patent: Page/Page column 15 ;
反应条件
3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine in ethanol T=90°C; 1.5 h;
参考文献
US2011/150834 A1, ;
Page/Page column 60-61 ;
