1-(1H-吡唑-1-基)-2-丙胺合成路线 （共 7 条）
反应条件
1: With thionyl chloride
T=50°C;
2: With sodium hydrogencarbonate in ethyl acetate
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
Location in patent: Page/Page column 111 ;
WO 2012/018635 A2
反应条件
in methanol; hexane; benzene
0.166667 h;
参考文献
CONCERT PHARMACEUTICALS INC.; Tung, Roger
Patent: US2014/128469 A1, 2014 ;
Location in patent: Paragraph 0110; 0112 ;
参考文献
Hoechst Aktiengesellschaft
Patent: US4010273 A1, 1977 ;
反应条件
1.1: sodium hydrogencarbonate / water / 85 °C
1.2: 20 °C
2.1: thionyl chloride / 50 °C
View Scheme
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
WO 2012/018635 A2
反应条件
1.1: sodium hydrogencarbonate / water / 85 °C
1.2: 20 °C
2.1: thionyl chloride / 50 °C
View Scheme
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
WO 2012/018635 A2
反应条件
in acetonitrile
T=20°C;
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
Location in patent: Page/Page column 111 ;
WO 2012/018635 A2
参考文献
Hoechst Aktiengesellschaft
Patent: US4010273 A1, 1977 ;
