2-氯甲基咪唑并[1,2-a]吡啶盐酸盐合成路线 （共 9 条）
反应条件
in ethylene glycol dimethyl ether; ethanol T=20°C; 0.25 h; Inert atmosphere;
参考文献
Henry, Nicolas; Thiery, Emilie; Petrignet, Julien; Halouchi, Hassan; Thibonnet, Jerome; Abarbri, Mohamed
European Journal of Organic Chemistry, 2012 , # 31 p. 6212 - 6217,6
反应条件
in ethanol T=77°C; 3 h; Molecular sieve;
参考文献
Wyeth
Patent: US2006/19965 A1, 2006 ;
Location in patent: Page/Page column 32 ;
US 20060019965 A1
反应条件
sodium chloride; sodium hydrogencarbonate in acetonitrile
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6251926 B1, 2001 ;
反应条件
copper(II) bis(trifluoromethanesulfonate) in 1,2-dichloro-ethane T=80°C; 3 h;
参考文献
Yadav; Subba Reddy; Gopal Rao; Srinivas; Narsaiah
Tetrahedron Letters, 2007 , vol. 48, # 43 p. 7717 - 7720
反应条件
1: 72 percent / ethyl acetate 2: glacial acetic acid / 80 - 100 °C 3: aq. NaHCO3 View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 38, # 5 p. 590 - 597
反应条件
in ethylene glycol dimethyl ether 48 h; Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 5 p. 1170 - 1176
反应条件
1: 76 percent / conc. H2SO4, HNO3 (d=1.38) / 2 h / 20 °C 2: other nitro-compounds View Scheme
参考文献
Vanelle; Madadi; Roubaud; Maldonado; Crozet
Tetrahedron, 1991 , vol. 47, # 28 p. 5173 - 5184
反应条件
sodium hydride
1) DMF, 0.5 h, 2) 95-100 deg C, 24 h; Yield given. Multistep reaction;
参考文献
Sundberg; Dahlhausen; Manikumar; Mavunkel; Biswas; Srinivasan; King Jr.; Waid
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 1 p. 129 - 137
反应条件
sodium cyanide in ethanol; water
参考文献
Abbott Laboratories; Abbott GmbH and Co. KG
Patent: US2013/5705 A1, 2013 ;
US 20130005705 A1
