5-羟基-2-甲基苯甲酸合成路线 （共 26 条）
反应条件
in methanol; diethyl ether; dichloromethane T=20°C; 72 h;
参考文献
PFIZER JAPAN INC.; HASHIZUME, Yoshinobu; PFIZER INC.
Patent: WO2005/92858 A2, 2005 ;
Location in patent: Page/Page column 99 ;
WO 2005/092858 A2
参考文献
Einhorn; Pfyl
Justus Liebigs Annalen der Chemie, 1900 , vol. 311, p. 55
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C; 16 h;
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
参考文献
Peltier
Bulletin de la Societe Scientifique de Bretagne, 1956 , vol. 31, p. Sonderheft S.9,41
反应条件
1: aqueous hydrochloric acid
2: chromium (VI)-oxide; acetic acid
3: aq. NaOH solution / anschliessend ansaeuern mit wss. Salzsaeure
4: aq. NaOH solution
5: KMnO4; aqueous NaOH
6: KMnO4; aqueous KOH
View Scheme
参考文献
Charlesworth et al.
Canadian Journal of Chemistry, 1954 , vol. 32, p. 941,945
反应条件
in tetrahydrofuran; diethyl ether
T=-78 - 25°C; 17 h; Inert atmosphere;
参考文献
Lafleur, Karine; Huang, Danzhi; Zhou, Ting; Caflisch, Amedeo; Nevado, Cristina
Journal of Medicinal Chemistry, 2009 , vol. 52, # 20 p. 6433 - 6446
