1,3-二丁基-嘧啶-2,4,6-三酮合成路线 （共 6 条）
反应条件
1: carbon disulfide; 1,3-dibutyl-pyrimidine-2,4,6-trione With triethylamine in dimethyl sulfoxide T=22°C; 1 h; 2: 1,3-dibromo-propane in dimethyl sulfoxide T=23°C; 12 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/77918 A1, 2005 ;
Location in patent: Page/Page column 13 ;
WO 2005/077918 A1
反应条件
acetic anhydride in acetic acid
T=80 - 90°C; 2.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/77918 A1, 2005 ;
Location in patent: Page/Page column 12-13 ;
WO 2005/077918 A1
反应条件
sodium nitrite in hydrogenchloride
参考文献
The Procter and Gamble Company
Patent: US5456904 A1, 1995 ;
反应条件
acetic anhydride; acetic acid
T=25 - 90°C; 17 h;
参考文献
Klikar, Milan; Bures, Filip; Pytela, Oldrich; Mikysek, Tomas; Padelkova, Zdenka; Barsella, Alberto; Dorkenoo, Kokou; Achelle, Sylvain
New Journal of Chemistry, 2013 , vol. 37, # 12 p. 4230 - 4240
反应条件
1: N-butylamine; n-butyl isocyanante in dichloromethane
2 h;
2: malonoyl dichloride in dichloromethane
2 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/150011 A2, 2007 ;
Location in patent: Page/Page column 100 ;
反应条件
1: dichloromethane / 1 h / 25 °C
2: acetic acid; acetic anhydride / 17 h / 25 - 90 °C
View Scheme
参考文献
Klikar, Milan; Bures, Filip; Pytela, Oldrich; Mikysek, Tomas; Padelkova, Zdenka; Barsella, Alberto; Dorkenoo, Kokou; Achelle, Sylvain
New Journal of Chemistry, 2013 , vol. 37, # 12 p. 4230 - 4240
