1-丙基-1H-苯并咪唑-2-胺合成路线 （共 5 条）
反应条件
1: 2-amino-1H-benzimidazole With potassium hydroxide in tetrahydrofuran; ethanol T=20°C; 0.333333 h; Inert atmosphere; 2: propyl bromide in tetrahydrofuran; ethanol T=65°C; 72 h; Inert atmosphere;
参考文献
GLAXOSMITHKLINE LLC; LAFRANCE, Louis, Vincent; LEBER, Jack, Dale; LI, Mei; VERMA, Sharad, Kumar
Patent: WO2010/126922 A1, 2010 ;
Location in patent: Page/Page column 15 ;
WO 2010/126922 A1
反应条件
potassium carbonate; potassium hydroxide in acetone 3 h; Reflux;
参考文献
Di Braccio, Mario; Grossi, Giancarlo; Signorello, Maria Grazia; Leoncini, Giuliana; Cichero, Elena; Fossa, Paola; Alfei, Silvana; Damonte, Gianluca
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 564 - 578
反应条件
sodium carbonate in acetonitrile T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 7 p. 2414 - 2419
反应条件
potassium hydroxide in acetone T=20°C;
参考文献
European Journal of Medicinal Chemistry, , vol. 41, # 9 p. 1080 - 1083
反应条件
ammonium hydroxide T=145 - 150°C; 5 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 18 p. 6291 - 6297
