1,2-二氢-4-羟基-1-甲基-2-氧代-3-喹啉羧酸乙酯合成路线 （共 19 条）
反应条件
in toluene 6 h; Heating;
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
参考文献
Ukrainets, I.V.; Bezuglyi, P.A.; Gorokhova, O.V.; Treskach, V.I.; Turov, A.V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1993 , vol. 29, # 1 p. 92 - 94
Khimiya Geterotsiklicheskikh Soedinenii, 1993 , # 1 p. 105 - 108
反应条件
sodium hydroxide 3 h; Heating;
参考文献
Coppola, Gary M.; Damon, Robert E.; Hardtmann, Goetz E.
Synthesis, 1981 , # 5 p. 391 - 392
反应条件
sodium hydride in N,N-dimethyl-formamide
T=120°C; 2.5 h;
参考文献
Ismaili, Lhassane; Refouvelet, Bernard; Robert, Jean Francois
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 3 p. 719 - 722
反应条件
1: methyl 2-(methylamino)benzoate; malonoyl dichloride With 4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=0 - 20°C; 5 h; Inert atmosphere;
2: sodium ethanolate With hydrogenchloride in ethanol; water
T=20°C; RefluxInert atmosphere;
参考文献
Carrer, Amandine; Brion, Jean-Daniel; Messaoudi, Samir; Alami, Mouad
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 2044 - 2054
反应条件
sodium hydride in tetrahydrofuran
T=20°C; 2.5 h;
参考文献
Zikou, Lamprini; Athanasellis, Giorgos; Detsi, Anastasia; Zografos, Alexandros; Mitsos, Christos; Igglessi-Markopoulou, Olga
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 8 p. 1505 - 1508
反应条件
benzoic acid in ethyl acetate
48 h; Heating;
参考文献
Kamel, Azza A.; Abdou, Wafaa M.
Synlett, 2007 , # 8 p. 1269 - 1273
反应条件
1: NaH / dimethylformamide / 5 h / 20 °C
2: NaH / dimethylformamide / 5 h / 85 °C
View Scheme
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
反应条件
1: dioxane / 1 h / 20 °C
2: NaH / dimethylformamide / 5 h / 20 °C
3: NaH / dimethylformamide / 5 h / 85 °C
View Scheme
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
反应条件
1: Et3N / CH2Cl2 / 8 h / Ambient temperature
2: aq. KOH / 5 h
3: 96 percent / aq. HCl / 1 h
View Scheme
参考文献
Ukrainets, I.V.; Gorokhova, O.V.; Taran, S.G.; Bezuglyi, P.A.; Turov, A.V.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994 , vol. 30, # 7 p. 829 - 836
Khimiya Geterotsiklicheskikh Soedinenii, 1994 , # 7 p. 958 - 966
