5-溴噻吩-2-甲酸乙酯合成路线 （共 23 条）
反应条件
ethanol; sulfuric acid Heating / reflux;
参考文献
ARROW THERAPEUTICS LIMITED
Patent: WO2009/34390 A1, 2009 ;
Location in patent: Page/Page column 28 ;
WO 2009/034390 A1
反应条件
1: 2,5-dibromothiophene With iso-propylmagnesium bromide in tetrahydrofuran T=-5°C; Grignard reaction; 0.5 h; 2: [(Cyanocarbonyl)oxy]ethane Alkylation;
参考文献
Abarbri, Mohamed; Dehmel, Florian; Knochel, Paul
Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7449 - 7453
反应条件
manganese(IV) dioxide; acetic acid in ethanol; water
反应条件
4-(N,N-dimethlyamino)pyridine; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide T=20°C;
参考文献
EP1630157 A1, ;
Page/Page column 56 ;
EP 1630157 A1
反应条件
1: 2,5-dibromothiophene With magnesium; ethylene dibromide in tetrahydrofuran 1.5 h; sonification; 2: diethyl dicarbonate With aluminium trichloride in tetrahydrofuran T=20°C; Barbier carboxylation; 5 h;
参考文献
Synthesis, , # 4 p. 568 - 572
反应条件
benzyltrimethylammonium bromide dibromide; zinc(II) chloride in acetic acid 17 h; Ambient temperature;
参考文献
Okamoto, Tsuyoshi; Kakinami, Takaaki; Fujimoto, Hiroshi; Kajigaeshi, Shoji
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 8 p. 2566 - 2568
参考文献
Journal of the Chemical Society, , p. 547
反应条件
molybdenum hexacarbonate T=150°C; 6 h; Inert atmosphereAutoclave;
参考文献
Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev
Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478
反应条件
1: With pyridine; iodine; copper(II) oxide 24 h; Reflux; 2: With potassium carbonate 8 h; Reflux;
参考文献
Yin, Guodong; Gao, Meng; Wang, Zihua; Wu, Yandong; Wu, Anxin
Bulletin of the Chemical Society of Japan, 2008 , vol. 81, # 3 p. 369 - 372
反应条件
in acetic acid T=20°C; activation energy; Rate constantThermodynamic data;
参考文献
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, , vol. 27, # 6 p. 538 - 539
