3-氯-3-(4-甲氧基苯基)丙烯腈合成路线 （共 12 条）
反应条件
sodium 1.) methanol or ethanol, room temp., 2.) reflux, 10 min; Yield given. Multistep reaction;
参考文献
Sahner, J. Henning; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 223 - 231
反应条件
in ethanol 5 h; Heating;
参考文献
Pharmazie, , vol. 44, # 8 p. 535 - 539
反应条件
hydrazine hydrate in ethanol 5 h; Heating;
参考文献
Hartmann, Horst; Liebscher, Juergen
Synthesis, 1984 , # 3 p. 276 - 277
反应条件
hydroxylamine hydrochloride; phosphorus trichoride
1) 30 min, RT, 2) 30 min, 200 deg C; Yield given. Multistep reaction;
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
1: NH2OH*HCl / dimethylformamide / 8 h / 110 °C
2: Ac2O / 18 h / Heating
View Scheme
参考文献
Migianu, Evelyne; Kirsch, Gilbert
Synthesis, 2002 , # 8 p. 1096 - 1100
反应条件
acetic anhydride
4 h; Heating;
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
1: 72 percent / POCl3 / 5 h / 60 °C
2: NH2OH*HCl / dimethylformamide / 8 h / 110 °C
3: Ac2O / 18 h / Heating
View Scheme
参考文献
Migianu, Evelyne; Kirsch, Gilbert
Synthesis, 2002 , # 8 p. 1096 - 1100
反应条件
1: 93 percent / H2N-OH*HCl / ethanol / Heating
2: 47 percent / acetic anhydride / 4 h / Heating
View Scheme
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
hydroxylamine hydrochloride; trichlorophosphate
1) 30 min, RT, 2) 30 min, 100 deg C; Yield given. Multistep reaction;
参考文献
Liebscher, Juergen; Neumann, Bernd; Hartmann, Horst
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 915 - 918
反应条件
potassium carbonate in tetrahydrofuran; ethanol
Heating;
参考文献
Migianu, Evelyne; Kirsch, Gilbert
Synthesis, 2002 , # 8 p. 1096 - 1100
