4-碘-3-硝基苯甲酸乙酯合成路线 （共 12 条）
反应条件
1: With phenyl-magnesium chloride in tetrahydrofuran T=-60°C; 0.0833333 h; 2: With boric acid trimethyl ester in tetrahydrofuran T=-60°C; 0.5 h; 3: With hydrogenchloride in tetrahydrofuran T=-20°C;
参考文献
Collibee, Scott E.; Yu, Jiaxin
Tetrahedron Letters, 2005 , vol. 46, # 26 p. 4453 - 4455
反应条件
1-methyl-pyrrolidin-2-one; 1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) in water T=150°C; 0.0833333 h; Microwave irradiation;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/75070 A1, 2008 ;
Location in patent: Page/Page column 147-148 ;
WO 2008/075070 A1
反应条件
sulfuric acid; nitric acid
T=20°C; 5 h;
参考文献
Sapountzis, Ioannis; Dube, Henry; Lewis, Robert; Gommermann, Nina; Knochel, Paul
Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2445 - 2454
反应条件
sulfuric acid
RefluxInert atmosphere;
参考文献
Curiel, David; Sanchez, Guzman; Ramirez De Arellano, Carmen; Tarraga, Alberto; Molina, Pedro
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 9 p. 1896 - 1904
反应条件
toluene-4-sulfonic acid; potassium iodide; sodium nitrite in water; acetonitrile
T=10 - 20°C;
参考文献
Li, Xinyu; Li, Cheng; Zhang, Wenjing; Lu, Xiang; Han, Shiqing; Hong, Ran
Organic Letters, 2010 , vol. 12, # 8 p. 1696 - 1699
反应条件
1: aqueous hydrochloric acid; sodium nitrite / Diazotization.Erwaermen der erhaltenen Diazoniumsalz-Loesung mit wss. Kaliumjodid-Loesung
2: sulfuric acid; aqueous nitric acid
View Scheme
参考文献
Searle; Adams
Journal of the American Chemical Society, 1933 , vol. 55, p. 1649,1652
反应条件
1: fuming nitric acid / man giesst dann in Eiswasser
2: HCl
View Scheme
参考文献
Allen
Chemische Berichte, 1893 , vol. 26, p. 1739
参考文献
Allen
Chemische Berichte, 1893 , vol. 26, p. 1739
参考文献
Searle; Adams
Journal of the American Chemical Society, 1933 , vol. 55, p. 1649,1652
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethylene glycol dimethyl ether; water / 18 h / Reflux; Inert atmosphere
2: triphenylphosphine / 1,2-dichloro-benzene / Inert atmosphere
View Scheme
参考文献
Curiel, David; Sanchez, Guzman; Ramirez De Arellano, Carmen; Tarraga, Alberto; Molina, Pedro
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 9 p. 1896 - 1904
