1-甲基-5-三氟甲基-1H-吲唑-3-胺合成路线 （共 3 条）
反应条件
potassium hydroxide; hydroxylamine hydrochloride in ethanol; water T=20 - 100°C;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA SAN DIEGO, INC.
Patent: WO2007/75847 A2, 2007 ;
Location in patent: Page/Page column 89-91 ;
WO 2007/075847 A2
反应条件
dimethyl sulfate in nitrobenzene; butan-1-ol
反应条件
in isopropyl alcohol 2 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6042 - 6048
