(R)-(-)-2-氯-1-苯乙醇合成路线 （共 34 条）
反应条件
hydrogen; catalyst prepared from Ru[(S,S)-Tsdpen](p-cymene) and HBF4 in methanol; tert-butyl alcohol T=30°C; P=38002.6 Torr; 24 h; Product distribution / selectivity;
参考文献
NAGOYA INDUSTRIAL SCIENCE RESEARCH INSTITUTE
Patent: US2008/234525 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
formic acid*triethylamine; Ru/(S,S)-DPEN/MCF in dichloromethane T=20°C; 12 h;
参考文献
Huang, Xiaohua; Ying, Jackie Y.
Chemical Communications, 2007 , # 18 p. 1825 - 1827
反应条件
(η5-C5Ph5)Ru(CO)2Cl; PS-C "Amano II"; potassium tert-butylate; sodium carbonate in tetrahydrofuran; toluene T=20°C; 13 h;
参考文献
Martin-Matute, Belen; Edin, Michaela; Bogar, Krisztian; Kaynak, F. Betuel; Baeckvall, Jan-E.
Journal of the American Chemical Society, 2005 , vol. 127, # 24 p. 8817 - 8825
反应条件
oxygen; lithium chloride; copper dichloride; {Pd2(MeCN)2(PHT)[(S)-Tol-BINAP]}(BF4)2 in tetrahydrofuran; water T=25°C; P=760 Torr; Title compound not separated from byproducts;
参考文献
Journal of Organometallic Chemistry, , vol. 656, # 1-2 p. 168 - 176
反应条件
triethylamine; Cp*RhCl((1R,2R)-N-p-tosyl-1,2-diphenylethylenediamine) in ethyl acetate T=25°C; 2 h;
参考文献
Organic Letters, , vol. 4, # 24 p. 4373 - 4376
反应条件
triethylamine; planar-chiral DMAP derivative in 1,1-dimethylpropan-1-ol T=0°C; Acetylation;
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2794 - 2795
反应条件
isopropyl alcohol in various solvent(s) T=30°C; pH=7.5; 5 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 8-9 p. 1399 - 1404
反应条件
1: 2-chloro-acetophenone With aluminum oxide; sodium tetrahydroborate in hexane T=40°C; 3 h; 2: 2-acetyloxy-1-propene With Lipase 'Amano' PS-C II in hexane T=25°C; 10 h;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 8 p. 815 - 820
反应条件
1: 1-hydroxy-2-chloroethylbenzene With Burkholderia cepacia lipase in diethyl ether T=30°C; 0.5 h; Enzymatic reaction; 2: vinyl acetate in diethyl ether T=30°C; 2.5 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ema, Tadashi; Ura, Norichika; Yoshii, Masataka; Korenaga, Toshinobu; Sakai, Takashi
Tetrahedron, 2009 , vol. 65, # 46 p. 9583 - 9591
反应条件
chiral 2-(3',5'-di-t-butylPh)-2-phosphabicyclo[3.3.0]octane in n-heptane T=-20°C; 1.3 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 125, # 14 p. 4166 - 4173
