4-苯基-2-氮杂环丁酮合成路线 （共 52 条）
反应条件
1: 97 percent / tetrabutylammonium hydrogen sulfate, KOH / tetrahydrofuran / 5 h / Ambient temperature 2: 75 percent / 168 h / Ambient temperature 3: NH3 liquid / 336 h / 70 °C View Scheme
参考文献
Begley, Michael J.; Crombie, Leslie; Haigh, David; Jones, Raymond C. F.; Osborne, Steven; Webster, Richard A. B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 17 p. 2027 - 2046
反应条件
1: 97 percent / tetrabutylammonium hydrogen sulfate, KOH / tetrahydrofuran / 5 h / Ambient temperature 2: 75 percent / 168 h / Ambient temperature 3: NH3 liquid / 336 h / 70 °C View Scheme
参考文献
Begley, Michael J.; Crombie, Leslie; Haigh, David; Jones, Raymond C. F.; Osborne, Steven; Webster, Richard A. B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 17 p. 2027 - 2046
反应条件
AlCl3, aluminium chloride
1 h; Reflux;
参考文献
King, Frank D.; Caddick, Stephen
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 16 p. 3244 - 3252
反应条件
1: 69 percent / KOH, DMSO / 23 h
2: 14 percent / 144 h / 90 °C
View Scheme
参考文献
Begley, Michael J.; Crombie, Leslie; Haigh, David; Jones, Raymond C. F.; Osborne, Steven; Webster, Richard A. B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 17 p. 2027 - 2046
反应条件
1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C
2: trifluorormethanesulfonic acid / chloroform / 3 h / |Reflux
View Scheme
参考文献
King, Frank D.; Caddick, Stephen
Tetrahedron, 2012 , vol. 68, # 46 p. 9350 - 9354
反应条件
potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in tetrahydrofuran
5 h; Ambient temperature;
参考文献
Begley, Michael J.; Crombie, Leslie; Haigh, David; Jones, Raymond C. F.; Osborne, Steven; Webster, Richard A. B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 17 p. 2027 - 2046
参考文献
Crombie, Leslie; Jones, Raymond C. F.; Osborne, Steven; Mat-Zin, Ab. Rasid
Journal of the Chemical Society, Chemical Communications, 1983 , # 17 p. 959 - 960
反应条件
1: 94 percent / KOH, Bu4NHSO4 / tetrahydrofuran / 20 °C
2: 90 percent / liq. NH3 / 144 h / 20 °C / sealed tube
3: 90 percent / NaBH3CN
4: KOH / dimethylsulfoxide
View Scheme
参考文献
Crombie, Leslie; Jones, Raymond C. F.; Mat-Zin, Ab. Rasid; Osborne, Steven
Journal of the Chemical Society, Chemical Communications, 1983 , # 17 p. 960 - 961
反应条件
1: 94 percent / KOH, Bu4NHSO4 / tetrahydrofuran / 20 °C
2: 90 percent / liq. NH3 / 144 h / 20 °C / sealed tube
3: 90 percent / NaBH3CN
View Scheme
参考文献
Crombie, Leslie; Jones, Raymond C. F.; Haigh, David
Tetrahedron Letters, 1986 , vol. 27, # 42 p. 5147 - 5150
反应条件
potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in tetrahydrofuran
T=20°C;
参考文献
Crombie, Leslie; Jones, Raymond C. F.; Osborne, Steven; Mat-Zin, Ab. Rasid
Journal of the Chemical Society, Chemical Communications, 1983 , # 17 p. 959 - 960
