(R)-(+)-3-苄氧基-1,2-丙二醇合成路线 （共 67 条）
反应条件
1: 85 percent / triethylamine / 2-methyl-propan-2-ol / 24 h / 60 °C
2: 91 percent / triethylamine / CH2Cl2 / -10 - 20 °C
3: isobutanol / 20 h / Heating
4: potassium hydroxide / acetone / 20 °C
View Scheme
参考文献
Bolchi, Cristiano; Pallavicini, Marco; Fumagalli, Laura; Moroni, Barbara; Rusconi, Chiara; Valoti, Ermanno
Tetrahedron Asymmetry, 2005 , vol. 16, # 20 p. 3380 - 3384
参考文献
Volkova,L.V. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 6 p. 1848 - 1851,1798 - 1800
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine
参考文献
VASCULAR BIOGENICS LTD.; KOVALEVSKI-ISHAI, Eti; ZINIUK, Zeev; HALPERIN, Gideon; MENDEL, Itzhak; FEIGE, Erez; YACOV, Niva; BREITBART, Eyal
Patent: WO2010/52718 A1, 2010 ;
Location in patent: Page/Page column 117-118 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in benzene
20 h; Heating;
参考文献
Takano, Seiichi; Seya, Kazuhiko; Goto, Emiko; Hirama, Michiyasu; Ogasawara, Kunio
Synthesis, 1983 , # 2 p. 116 - 117
反应条件
triphenylphosphine; diethylazodicarboxylate in benzene
20 h; Heating; Yield given. Title compound not separated from byproducts;
参考文献
Gurjar; Sarma; Sadalapure; Adhikari
Synthesis, 1998 , # 10 p. 1424 - 1424
反应条件
1: 66 percent / pyridine
2: 66 percent / KOH / dimethylsulfoxide / 8 h / 20 °C
3: PPTS / methanol / 0.17 h / Heating
View Scheme
参考文献
Wickberg
Acta Chemica Scandinavica (1947-1973), 1958 , vol. 12, p. 1187,1195
反应条件
potassium hydroxide in dimethyl sulfoxide
T=20°C; 8 h; Yield given. Title compound not separated from byproducts;
参考文献
El'perina, E. A.; Struchkova, M. I.; Serkebaev, M. I.; Serebryakov, E. P.
Russian Chemical Bulletin, 1993 , vol. 42, # 4 p. 744 - 750
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1993 , # 4 p. 776 - 781
