3,6,9,12-四氧十四烷-1-醇合成路线 （共 9 条）
反应条件
potassium hydroxide in tetrahydrofuran
Ambient temperature;
参考文献
Philippen, Annie; Degueil-Castaing, Marie; Beckwith, Athelstan L. J.; Maillard, Bernard
Journal of Organic Chemistry, 1998 , vol. 63, # 20 p. 6814 - 6819
反应条件
1: tetraethylene glycol With sodium hydride in tetrahydrofuran
1 h; Heating;
2: ethyl bromide in tetrahydrofuran
T=0°C; 1 h;
参考文献
Cao, Yang; Zhang, Minjia; Wu, Cindy; Lee, Selina; Wroblewski, Mary Elizabeth; Whipple, Trisha; Nagy, Peter I.; Takacs-Novak, Krisztina; Balazs, Attila; Toroes, Szilard; Messer Jr., William S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4273 - 4286
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; 120 h;
参考文献
Dong, Chang-Zhi; Ahamada-Himidi, Azali; Plocki, Stephanie; Aoun, Darina; Touaibia, Mohamed; Meddad-Bel Habich, Nadia; Huet, Jack; Redeuilh, Catherine; Ombetta, Jean-Edouard; Godfroid, Jean-Jacques; Massicot, France; Heymans, Francoise
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1989 - 2007
反应条件
1: triethylamine / diethyl ether / 18 h / 20 °C
2: 23 percent / NaH / dimethylformamide / 120 h / 20 °C
View Scheme
参考文献
Dong, Chang-Zhi; Ahamada-Himidi, Azali; Plocki, Stephanie; Aoun, Darina; Touaibia, Mohamed; Meddad-Bel Habich, Nadia; Huet, Jack; Redeuilh, Catherine; Ombetta, Jean-Edouard; Godfroid, Jean-Jacques; Massicot, France; Heymans, Francoise
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1989 - 2007
反应条件
sulfuric acid
T=80 - 100°C;
参考文献
I.G.Farbenind.
Patent: DE542765 , 1925 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 174
反应条件
ethanolamine
T=50 - 60°C;
参考文献
Union Carbide and Carbon Corp.
Patent: US2053708 , 1934 ;
参考文献
Hiratani,K. et al.
Israel Journal of Chemistry, 1979 , vol. 18, p. 208 - 213
反应条件
sodium
1) 100-120 deg C, 2) 100-120 deg C, 2-3 h; Yield given. Multistep reaction;
参考文献
Heimann, Ulrich; Voegtle, Fritz
Liebigs Annalen der Chemie, 1980 , # 6 p. 858 - 862
参考文献
Union Carbide and Carbon Corp.
Patent: US2053708 , 1934 ;
