4-甲基-1-戊炔-3-醇合成路线 （共 30 条）
参考文献
Logemann et al.
Farmaco, Edizione Scientifica, 1953 , vol. 8, p. 406,409
反应条件
1: palladium/calcium carbonate / Hydrogenation
2: aluminium phosphate / 300 - 310 °C
3: zirconium (IV)-oxide /pumice stone / 300 - 310 °C
View Scheme
参考文献
Nasarow; Mawrow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959 , p. 472,482; engl. Ausg. S. 446, 454
反应条件
1: palladium/calcium carbonate / Hydrogenation
2: aluminium phosphate / 300 - 310 °C
View Scheme
参考文献
Nasarow; Mawrow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959 , p. 472,482; engl. Ausg. S. 446, 454
反应条件
in dichloromethane
T=-5 - 20°C; 16 h; Yield given. Yields of byproduct given;
参考文献
Bridges, Alexander J.
Tetrahedron Letters, 1980 , vol. 21, p. 4401 - 4404
反应条件
Mo(CO)3(CN-t-Bu)3; hydroquinone in tetrahydrofuran
T=55 - 60°C; 12 h; Inert atmosphere; Overall yield = 84 percent; Overall yield = 327 mg;
参考文献
Maleczka Jr., Robert E.; Ghosh, Banibrata; Gallagher, William P.; Baker, Aaron J.; Muchnij, Jill A.; Szymanski, Amy L.
Tetrahedron, 2013 , vol. 69, # 19 p. 4000 - 4008
反应条件
zinc trifluoromethanesulfonate in toluene
T=100°C;
参考文献
Kumar, Manyam Praveen; Liu, Rai-Shung
Journal of Organic Chemistry, 2006 , vol. 71, # 13 p. 4951 - 4955
反应条件
quinoline; hydrogen; Lindlar catalyst in pentane
P=760 Torr;
参考文献
Less, Simon L.; Handa, Sandeep; Millburn, Karen; Leadlay, Peter F.; Dutton, Christopher J.; Staunton, James
Tetrahedron Letters, 1996 , vol. 37, # 20 p. 3515 - 3518
反应条件
1: (RS)-4-methyl-1-pentyn-3-ol With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 22°C;
2: chloro-trimethyl-silane in tetrahydrofuran; hexane
T=-78 - 22°C; Further stages.;
参考文献
Kacprzynski, Monica A.; Kazane, Stephanie A.; May, Tricia L.; Hoveyda, Amir H.
Organic Letters, 2007 , vol. 9, # 16 p. 3187 - 3190
反应条件
1: 74 percent / Triethylamin / CH2Cl2
2: 1.) Et2NH or EtOH, 2.) 10percent aq. HCl / 1.) ether, room temp., 12 h, 2.) 24h, room temp.
View Scheme
参考文献
Altenbach, Hans-Josef; Korff, Rainer
Tetrahedron Letters, 1981 , vol. 22, # 51 p. 5175 - 5178
反应条件
1: 1.) LiN(C3H7-i)2 / 1.) THF, hexamethylphosphoric triamide, -78 deg C, 75 min., 2.) -78 deg C, 1 h -> room temp., 1 h
2: 73 percent / Collins' reagent / CH2Cl2 / 0.58 h / Ambient temperature
View Scheme
参考文献
Smith, Amos B.; Levenberg, Patricia A.; Suits, Joan Z.
Synthesis, 1986 , # 3 p. 184 - 189
