5-羟基-3,4-二氢-2H-异喹啉-1-酮合成路线 （共 8 条）
反应条件
sodium azide; trichloroacetic acid T=70°C; Addition; 18 h;
参考文献
Miyake, Yoshinori; Shimadzu, Hiroshi; Hashimoto, Naoto; Ishida, Yoshio; Shibakawa, Masahiko; Nishimura, Tsunehiko
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 10 p. 983 - 988
反应条件
hydrogen; palladium on activated charcoal in acetic acid T=50°C;
参考文献
Showalter; Sercel; Stier; Turner
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 4 p. 961 - 964
反应条件
hydrogen; palladium monocarbide in ethanol; acetonitrile
参考文献
US4847264 A1, ;
US 4847264 A
反应条件
potassium carbonate in ethanol; chloroform
反应条件
1: 3,4-dihydro-5-hydroxy-1(2H)-isoquinolinone With potassium carbonate in ethanol 1 h; Heating; 2: 1-bromo-3-chloro-propane in ethanol 2 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 38, # 4 p. 961 - 964
反应条件
1: 3,4-dihydro-5-hydroxy-1(2H)-isoquinolinone With caesium carbonate in N,N-dimethyl-formamide T=50°C; 0.333333 h; 2: methyl iodide in N,N-dimethyl-formamide T=50°C; 0.5 h;
参考文献
NOVARTIS AG; ATKINSON, Benjamin; BEATTIE, David; CULSHAW, Andrew James; DALE, James; DEVEREUX, Nicholas James; MCKENNA, Jeffrey
Patent: WO2011/92293 A2, 2011 ;
Location in patent: Page/Page column 91 ;
WO 2011/092293 A1
反应条件
sodium hydroxide in acetone T=20°C; Etherification; 3 h;
参考文献
Miyake, Yoshinori; Shimadzu, Hiroshi; Hashimoto, Naoto; Ishida, Yoshio; Shibakawa, Masahiko; Nishimura, Tsunehiko
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 10 p. 983 - 988
反应条件
dimethyl sulfate in methanol; sodium hydroxide; water
参考文献
Warner-Lambert Company
Patent: US5177075 A1, 1993 ;
