反应条件
1: 86 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 2: 1.) NaH / 1.) DMF, 2.) DMF, 60 deg, 18 h 3: 84 percent / H2 / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr 4: 1.) NaH / 1.) DMF, 2.) DMF, 50-60 deg, 6 h 5: water, HCl View Scheme
参考文献
Manoury; Binet; Rousseau; Lefevre-Borg; Cavero
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1003 - 1011
