4-(2-二甲基氨基乙基)-苯胺合成路线 （共 13 条）
反应条件
sulfuric acid durch Diazotieren;
参考文献
Kindler
Patent: DE396453 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 401
反应条件
palladium on activated charcoal; hydrogen in methanol
P=2327.23 Torr; 16 h;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00596 ;
WO 2013/043232 A2
反应条件
1: With trifluoroacetic acid
T=20°C; 0.5 h;
2: With sodium hydroxide in water
T=0°C;
3: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 70°C; 0.5 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1798221 A1, 2007 ;
Location in patent: Page/Page column 28 ;
反应条件
carbon dioxide
T=130°C; P=67505.4 Torr; 17 h;
参考文献
Selva, Maurizio; Tundo, Pietro; Perosa, Alvise; Dall'Acqua, Federico
Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2771 - 2777
参考文献
Kindler
Patent: DE396453 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 401
反应条件
1: water / 20 °C
2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux
3: 10 palladium on activated charcoal; hydrogen / methanol
View Scheme
参考文献
Wang, Li; Yang, Fenyan; Yang, Xiaochun; Guan, Xianghong; Hu, Chunqi; Liu, Tao; He, Qiaojun; Yang, Bo; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 285 - 296
反应条件
1: triphenylphosphine / dichloromethane / 0 °C
2: water / 20 °C
3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux
4: 10 palladium on activated charcoal; hydrogen / methanol
View Scheme
参考文献
Wang, Li; Yang, Fenyan; Yang, Xiaochun; Guan, Xianghong; Hu, Chunqi; Liu, Tao; He, Qiaojun; Yang, Bo; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 285 - 296
反应条件
1: potassium carbonate / methanol / 3 h / |Reflux
2: palladium on activated charcoal; hydrogen / methanol / 16 h / 2327.23 Torr
View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Hach; Horakova
Collection of Czechoslovak Chemical Communications, 1957 , vol. 22, p. 1068,1071
反应条件
sulfuric acid
Electrolysis.an Bleielektroden;
参考文献
Kindler
Justus Liebigs Annalen der Chemie, 1923 , vol. 431, p. 213
Chem. Zentralbl., 1923 , vol. 94, # II p. 403
