4-甲基-2,2-联吡啶合成路线 （共 21 条）
反应条件
selenium(IV) oxide; water in 1,4-dioxane Heating;
参考文献
Imperiali, Barbara; Prins, Thomas J.; Fisher, Stewart L.
Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1613 - 1616
反应条件
1: 2-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran
1.16667 h;
2: 2-benzenesulfonyl-4-methyl-pyridine in tetrahydrofuran
T=20°C; 5.16667 h;
参考文献
Kuraray Co., Ltd.
Patent: EP1548005 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
nickel(II) dibromide hydrate; sodium iodide in N,N-dimethyl-formamide
T=20°C; Electrochemical reactionInert atmosphere;
参考文献
Oliveira, Jadson L.; Silva, Maria J.; Florencio, Tupolevck; Urgin, Karne; Sengmany, Stephane; Leonel, Eric; Nedelec, Jean-Yves; Navarro, Marcelo
Tetrahedron, 2012 , vol. 68, # 10 p. 2383 - 2390
反应条件
nickel(II) dibromide hydrate; sodium iodide in N,N-dimethyl-formamide
T=20°C; Electrochemical reactionInert atmosphere;
参考文献
Oliveira, Jadson L.; Silva, Maria J.; Florencio, Tupolevck; Urgin, Karne; Sengmany, Stephane; Leonel, Eric; Nedelec, Jean-Yves; Navarro, Marcelo
Tetrahedron, 2012 , vol. 68, # 10 p. 2383 - 2390
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene
Stille-type cross-coupling; 48 h; Heating;
参考文献
Heller, Marcel; Schubert, Ulrich S.
Journal of Organic Chemistry, 2002 , vol. 67, # 23 p. 8269 - 8272
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; Negishi reaction; 24 h;
参考文献
Fang, Yuan-Qing; Hanan, Garry S.
Synlett, 2003 , # 6 p. 852 - 854
反应条件
ammonium acetate in methanol
T=65°C; Kroehnke;
参考文献
Constable, Edwin C.; Figgemeier, Egbert; Housecraft, Catherine E.; Olsson, Jerry; Zimmermann, Yves C.
Dalton Transactions, 2004 , # 13 p. 1918 - 1927
反应条件
1.1: 48percent HBr; Br2 / 1.5 h / -20 °C
1.2: aq. NaNO2 / -20 - 15 °C
1.3: 85 percent / aq. NaOH / -10 - 20 °C
2.1: 56 percent / Pd(PPh3)4 / toluene / 48 h / Heating
View Scheme
参考文献
Schubert, Ulrich S.; Eschbaumer, Christian; Heller, Marcel
Organic Letters, 2000 , vol. 2, # 21 p. 3373 - 3376
反应条件
camphor-10-sulfonic acid; Dess-Martin periodane
T=0°C; 1 h;
参考文献
Kelli-Basetti, Bernadette M.; Krodkiewska, Irena; Sasse, Wolfgang H. F.; Savage, G. Paul; Simpson, Gregory W.
Tetrahedron Letters, 1995 , vol. 36, # 2 p. 327 - 330
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); potassium carbonate in tetrahydrofuran
Suzuki-Miyaura cross-coupling; 24 h; RefluxInert atmosphere;
参考文献
Guetz, Christoph; Luetzen, Arne
Synthesis, 2010 , # 1 p. 85 - 90
