2,3-二氢苯并呋喃-5-甲醛合成路线 （共 30 条）
反应条件
trichlorophosphate T=70 - 90°C; 9.5 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1792899 A1, 2007 ;
Location in patent: Page/Page column 11 ;
反应条件
titanium tetrachloride in dichloromethane Vilsmeier-Haack reaction; 1 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1199304 A1, 2002 ;
Location in patent: Referential example 1 ;
EP 1199304 A1
反应条件
trichlorophosphate in water; N,N-dimethyl-formamide
参考文献
Ishida, Hajime; Fukuta, Makoto
Patent: US2004/18239 A1, 2004 ;
反应条件
tin(IV) chloride in dichloromethane Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 322 - 330
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Ojida, Akio; Tanaka, Toshimasa; Hara, Takahito; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 16 p. 4313 - 4336
反应条件
1: 2,4-dibromo-1-(2-chloro-ethoxy)-benzene With n-butyllithium in tetrahydrofuran T=-40°C; Metallation; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-40 - 20°C; Formylation; Parham cyclization;
参考文献
Plotkin, Michael; Chen, Sanyou; Spoors, P. Grant
Tetrahedron Letters, 2000 , vol. 41, # 14 p. 2269 - 2273
反应条件
in tetrahydrofuran; hexane; water; N,N-dimethyl-formamide
反应条件
titanium tetrachloride
参考文献
Kelly, David P.; Jenkins, Margot J.
Journal of Organic Chemistry, 1984 , vol. 49, # 3 p. 409 - 413
反应条件
1.1: K2CO3 / dimethylformamide 2.1: n-BiLu / tetrahydrofuran / -40 °C 2.2: 75 percent / tetrahydrofuran / -40 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 14 p. 2269 - 2273
反应条件
hydrogenchloride; aluminium trichloride; benzene
参考文献
Journal of the Chemical Society, , p. 2455,246
