4-(2-氨基乙基)-2-甲氧基苯酚合成路线 （共 34 条）
反应条件
oxygen; Cu(II) perchlorate; ascorbic acid powder in water
参考文献
Aihara; Higuchi; Hirobe
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 3 p. 842 - 844
反应条件
1.1: neat (no solvent) / 1 h / 70 °C 2.1: sodium tetrahydroborate / methanol / 5 h / 20 °C / |Reflux 2.2: pH 5 - 6 3.1: copper(II) sulfate / water / 2 h / 100 °C 3.2: 3 h / 100 °C 3.3: 2 h / 20 °C / pH 9 - 10 4.1: hydrogenchloride / water View Scheme
参考文献
Wang, Yan-Xiang; Kong, Wei-Jia; Li, Ying-Hong; Tang, Sheng; Li, Zheng; Li, Yang-Biao; Shan, Yong-Qiang; Bi, Chong-Wen; Jiang, Jian-Dong; Song, Dan-Qing
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 22 p. 6552 - 6558
反应条件
2: ethanolic sodium ethylate View Scheme
参考文献
Kratzl; Billek
Monatshefte fuer Chemie, 1952 , vol. 83, p. 1409,1416
反应条件
1: 54 percent / Ac2O
2: 98 percent / NaOMe
View Scheme
参考文献
Cederbaum, Fredrik; De Mesmaeker, Alain; Jeanguenat, Andre; Kempf, Hans-Joachim; Lamberth, Clemens; Schnyder, Anita; Zeller, Martin; Zeun, Ronald
Chimia, 2003 , vol. 57, # 11 p. 680 - 684
反应条件
1: 90.4 percent / Heating
2: POCl3 / acetonitrile / Heating
3: NaBH4
View Scheme
参考文献
Rice; Brossi
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 592 - 601
参考文献
Cederbaum, Fredrik; De Mesmaeker, Alain; Jeanguenat, Andre; Kempf, Hans-Joachim; Lamberth, Clemens; Schnyder, Anita; Zeller, Martin; Zeun, Ronald
Chimia, 2003 , vol. 57, # 11 p. 680 - 684
参考文献
Casagrande; Santangelo; Saini; Doggi; Gerli; Cerri
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 2 A p. 291 - 303
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran
Ambient temperature;
参考文献
Tanaka, Hitoshi; Nakamura, Takeshi; Ichino, Kazuhiko; Ito, Kazuo
Phytochemistry (Elsevier), 1989 , vol. 28, # 9 p. 2516 - 2517
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran
Ambient temperature;
参考文献
Tanaka, Hitoshi; Nakamura, Takeshi; Ichino, Kazuhiko; Ito, Kazuo
Phytochemistry (Elsevier), 1989 , vol. 28, # 9 p. 2516 - 2517
反应条件
hydrogenchloride
T=100°C; Pictet-Spengler reaction; 24 h;
参考文献
Seo, Jai Woong; Srisook, Ekaruth; Son, Hyo Jin; Hwang, Onyou; Cha, Young-Nam; Chi, Dae Yoon
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 6 p. 1160 - 1170
