9-甲基-9-氮杂双环[3.3.1]壬-3-酮合成路线 （共 24 条）
反应条件
potassium carbonate in methanol T=25°C; 2 h;
参考文献
Nicolaou; Montagnon; Baran; Zhong
Journal of the American Chemical Society, 2002 , vol. 124, # 10 p. 2245 - 2258
反应条件
triethylamine in diethyl ether 0.25 h;
参考文献
WO2006/92268 A1, ;
Page/Page column 28 ;
WO 2006/092268 A1
反应条件
sodium hydroxide; sodium salt of phosphorous acid in water T=20°C; mannich reaction;
参考文献
Journal of the American Chemical Society, , vol. 122, # 2 p. 263 - 273
反应条件
1: 88 percent / o-iodoxybenzoic acid / dimethylsulfoxide; fluorobenzene / 6 h / 65 °C 2: 77 percent / K2CO3 / methanol / 2 h / 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 10 p. 2245 - 2258
反应条件
1: Herstellung 2: aqueous sodium nitrite; aqueous hydrochloric acid 3: water / Beim Behandeln bei pH 2.5-4.5 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 73, p. 3416
Org. Synth. Coll. Vol., , vol. IV, p. 816
反应条件
1: aqueous sodium nitrite; aqueous hydrochloric acid 2: water / Beim Behandeln bei pH 2.5-4.5 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 73, p. 3416
Org. Synth. Coll. Vol., , vol. IV, p. 816
反应条件
mercury(II) diacetate; sodium cyanoborohydride; acetic acid 1.) H2O, reflux, 2 d, 2.) 5 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of the American Chemical Society, , vol. 113, # 24 p. 9286 - 9292
反应条件
1: 1) n-BuLi / 1) hexane, THF, -78 to 0 deg C, 0.5h 2) -78 to 25 deg C, 4-6h 2: ozonolysis 3: methanol; H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 28 p. 3965 - 3968
反应条件
in sehr verduennter waessriger Loesung im pH-Bereich 3-7 bei mehrtaegigem Stehenlassen bei Raumtemperatur;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 518, p. 1,25
反应条件
1: ozonolysis 2: methanol; H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 28 p. 3965 - 3968
