4-甲基哌嗪-1-甲酰氯 盐酸盐合成路线 （共 10 条）
反应条件
in chloroform 1. 2 h, ice bath, 2. r.t., 2 h;
参考文献
Sharma, Satyavan; Agarwal, V. K.; Dubey, S. K.; Iyer, R. N.; Anand, Nitya; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 748 - 751
反应条件
sodium hydrogencarbonate in dichloromethane; water T=5 - 10°C; pH=7.5 - 8; 0.5 h;
参考文献
USV LIMITED
Patent: WO2009/63486 A2, 2009 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 4-methylpiperazin-1-ylcarbonyl chloride hydrochloride With triethylamine in dichloromethane T=5°C; 0.416667 h; 2: With 4-(N,N-dimethlyamino)pyridine in dichloromethane 0.0166667 - 0.0333333 h; 3: 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydropyrrolo[3,4-b]pyrazin-5-one in dichloromethane T=20°C; 7 h; Heating / reflux; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2008/2629 A1, 2008 ;
Location in patent: Page/Page column 13 ;
反应条件
pyridine; sodium hydroxide; triethylamine in diethyl ether; ethanol; dichloromethane; di-isopropyl ether; acetonitrile
参考文献
Rhone-Poulenc Industries
Patent: US4124711 A1, 1978 ;
反应条件
triethylamine in methanol; benzene Heating;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 748 - 751
反应条件
triethylamine in methanol; benzene Heating;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 748 - 751
反应条件
triethylamine in methanol; benzene Heating;
参考文献
Sharma, Satyavan; Agarwal, V. K.; Dubey, S. K.; Iyer, R. N.; Anand, Nitya; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 748 - 751
反应条件
triethylamine; hydrazine in methanol; benzene
Heating;
参考文献
Sharma, Satyavan; Agarwal, V. K.; Dubey, S. K.; Iyer, R. N.; Anand, Nitya; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 748 - 751
反应条件
triethylamine in chloroform
1.) 28 deg C, 1 h, 2.) reflux, 4 h;
参考文献
Mei-lin Go; Tong-lan Ngiam; Wan
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1471 - 1475
反应条件
pyridine; triethylamine in dichloromethane; water; ethyl acetate
参考文献
Rhone-Poulenc S.A.
Patent: US4016274 A1, 1977 ;
