5 -氨基- 1,3-二甲基-4 -腈-1H -吡唑合成路线 （共 7 条）
反应条件
in ethanol 2.5 h; Heating / reflux;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2006/35061 A1, 2006 ;
Location in patent: Page/Page column 45; 46 ;
反应条件
in water Ambient temperature;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 4 p. 1093 - 1096
参考文献
Taylor; Hartke
Journal of the American Chemical Society, 1959 , vol. 81, p. 2452,2455
反应条件
in acetonitrile T=95°C; In a sealed tube;
参考文献
Bergman, Jeffrey M.; Breslin, Michael J.; Coleman, Paul J.; Cox, Christopher D.; Mercer, Swati P.; Roecker, Anthony J.
Patent: US2008/132490 A1, 2008 ;
Location in patent: Page/Page column 24 ;
US 20080132490 A1
反应条件
sodium hydroxide; water; dihydrogen peroxide in methanol T=20°C; 3 h;
参考文献
GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG
Patent: WO2009/97446 A1, 2009 ;
Location in patent: Page/Page column 65 ;
WO 2009/097446 A1
反应条件
pyridine
T=0 - 20°C; Heating / reflux;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2006/35061 A1, 2006 ;
Location in patent: Page/Page column 45; 46 ;
反应条件
acetic acid
6 h; Reflux;
参考文献
Bamoharram, Fatemeh Farrash
Molecules, 2010 , vol. 15, # 4 p. 2509 - 2519
