3-羟基-2-氨基苯甲酸合成路线 （共 43 条）
反应条件
in methanol; diethyl ether T=0°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 17 p. 6106 - 6119
反应条件
potassium carbonate in dimethyl sulfoxide Methylation; 0.5 h;
参考文献
Tetrahedron, , vol. 56, # 46 p. 9057 - 9062
参考文献
Liebigs Annalen der Chemie, , # 8 p. 1515 - 1518
反应条件
thionyl chloride
anschliessende Umsetzung mit Glycin;
参考文献
Haberland et al.
Biochimica et Biophysica Acta, 1954 , vol. 15, p. 578,579
反应条件
toluene-4-sulfonic acid in hexan-1-ol
6 h; Heating;
参考文献
Herath; Mueller; Diyabalanage
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 1 p. 23 - 28
反应条件
1: 12 percent / CuCl, K2CO3 / 2-ethoxy-ethanol / 6 h / Heating
2: 59 percent / polyphosphoric acid (PPA) / 1 h / 115 °C
3: 66 percent / K2CO3 / propan-2-ol / 2 h / Heating
4: 78 percent / KOH / dimethylsulfoxide / 1 h / Ambient temperature
5: 20 percent / 6 N aq. HCl / ethanol / 4 h / Heating
View Scheme
参考文献
Kato; Fujita; Fujimura; Kawashima; Nishiyama
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 3 p. 445 - 452
反应条件
in sulfuric acid
3 h; Heating;
参考文献
Reisch, Johannes; Gunaherath, G. M. Kamal B.
Monatshefte fuer Chemie, 1988 , vol. 119, p. 1169 - 1178
反应条件
p-benozquinone in ethanol
T=20°C; 1 h; Inert atmosphere;
参考文献
Pasceri, Raffaele; Siegel, David; Ross, David; Moody, Christopher J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3310 - 3317
反应条件
oxygen
168 h; pH 6.5 - 7; Yield given. Yields of byproduct given;
参考文献
Manthey, Michael K.; Pyne, Stephen G.; Truscott, Roger J. W.
Journal of Organic Chemistry, 1988 , vol. 53, # 7 p. 1486 - 1488
反应条件
potassium phosphate; potassium hexacyanoferrate(III) in water
2 h; Ambient temperaturepH 7;
参考文献
Hick, Larry A.; Manthey, Michael K.; Truscott, Roger J. W.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 1157 - 1160
