1-(3-氯丙基)哌啶 单盐酸盐合成路线 （共 11 条）
反应条件
1: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in water; toluene T=40°C; 3 h; 2: With hydrogenchloride in methanol
参考文献
Toray Industries, Inc.
Patent: US6642228 B1, 2003 ;
Location in patent: Page/Page column 76-77 ;
反应条件
1: in toluene 4 h; Reflux; 2: With sodium hydroxide in toluene 1 h; Reflux; 3: With thionyl chloride T=20°C; Cooling with ice;
参考文献
CHINA PHARMACEUTICAL UNIVERSITY; Xiang, Hua; Wang, Tianlin; Xiao, Hong; You, Qidong; Yao, Yao; Li, Xiaobo; Liao, Qingjiang
Patent: US2013/85140 A1, 2013 ;
Location in patent: Paragraph 0054; 0055 ;
反应条件
thionyl chloride in tetrahydrofuran T=50°C; 2 h;
参考文献
Grassmann, Sven; Apelt, Joachim; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Archiv der Pharmazie, 2004 , vol. 337, # 10 p. 533 - 545
Title/Abstract Full Text View citing articles Show Details
Apelt; Grassmann; Ligneau; Pertz; Ganellin; Arrang; Schwartz; Schunack; Stark, Holger
Pharmazie, 2005 , vol. 60, # 2 p. 97 - 106
反应条件
1: KI / acetone / 12 h / Heating 2: SOCl2 / tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 5 p. 1128 - 1141
反应条件
potassium hydroxide; potassium iodide in water 12 h; Heating;
参考文献
Apelt, Joachim; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1128 - 1141
反应条件
hydrogen fluoride T=8 - 14°C; 5.23333 h; electrochemical fluorination: nickel electrodes, anodic current density: 4.0 A/dm2, cell voltage 5.2 - 8.2 V; Further byproducts given;
参考文献
Journal of Fluorine Chemistry, , vol. 23, p. 371 - 382
反应条件
hydrogen fluoride T=8 - 14°C; 5.23333 h; electrochemical fluorination: nickel electrodes, anodic current density: 4.0 A/dm2, cell voltage 5.2 - 8.2 V; Further byproducts given;
参考文献
Hayashi, Eiji; Abe, Takashi; Baba, Hajime; Nagase, Shunji
Journal of Fluorine Chemistry, 1983 , vol. 23, p. 371 - 382
反应条件
sodium ethanolate in ethanol 8 h; Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 24, p. 185 - 188
反应条件
sodium hydroxide; potassium carbonate in diethyl ether; water
1 h;
参考文献
Chen, Qingqi; Lopez, Rocio Alejandra; Heller, Jonathan Daniel; Morris, Amanda Jean
Patent: US2013/303531 A1, 2013 ;
Location in patent: Paragraph 0107; 0111; 0112 ;
反应条件
potassium hydroxide; potassium iodide in water
12 h; Heating;
参考文献
Apelt, Joachim; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1128 - 1141
