3-氨基-6-氯哒嗪合成路线

参考文献

NOVARTIS AG; DAI, Miao; FU, Xingnian; HE, Feng; JIANG, Lei; LI, Yue; LIANG, Fang; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YAN, Xiaoxia; YU, Zhengtian; ZHANG, Ji, Yue
Patent: WO2011/20861 A1, 2011 ;
Location in patent: Page/Page column 65 ;

5469-69-23-氨基-6-氯哒嗪+

1188-33-6N,N-二甲基甲酰胺二乙基缩醛

35053-55-5[2-(6-氯-3-吡嗪)-2-a氮杂乙烯基]二甲基胺

参考文献

IRM LLC
Patent: US2012/65184 A1, 2012 ;
Location in patent: Page/Page column 37 ;
US 20120065184 A1

5469-69-23-氨基-6-氯哒嗪+

1679-18-14-氯苯硼酸

58059-47-53-氨基-6-(4-氯苯基)哒嗪

参考文献

Gavande, Navnath; Johnston, Graham A. R.; Hanrahan, Jane R.; Chebib, Mary
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4131 - 4136

5469-69-23-氨基-6-氯哒嗪+

609-15-42-氯乙酰乙酸乙酯

14714-18-26-氯-2-甲基-咪唑并[2,1-f]吡嗪-3-羧酸乙酯

参考文献

Campbell, Alison N.; Cole, Kevin P.; Martinelli, Joseph R.; May, Scott A.; Mitchell, David; Pollock, Patrick M.; Sullivan, Kevin A.
Organic Process Research and Development, 2013 , vol. 17, # 2 p. 273 - 281

14714-18-26-氯-2-甲基-咪唑并[2,1-f]吡嗪-3-羧酸乙酯

参考文献

Takeda Chemical Industries, Ltd.
Patent: US6248740 B1, 2001 ;

5469-69-23-氨基-6-氯哒嗪+

108-24-7乙酸酐

14959-31-0N-(6-氯-3-哒嗪基)乙酰胺

参考文献

AAPA B.V.; HEERES, André; GROL, Cornelius Joannes; BORST, Marcus Leonardus Gerardus; WILLIGERS - Hogg, Sandra
Patent: WO2014/46544 A1, 2014 ;
Location in patent: Page/Page column 17; 29 ;

5469-69-23-氨基-6-氯哒嗪+

3282-30-2三甲基乙酰氯

147362-88-7

参考文献

Turck, Alain; Ple, Nelly; Ndzi, Bruno; Queguiner, Guy; Haider, Norbert; Schuller, Herbert; Heinisch, Gottfried
Tetrahedron, 1993 , vol. 49, # 3 p. 599 - 606

5469-69-23-氨基-6-氯哒嗪+

5720-07-04-甲氧基苯硼酸

4776-87-83-氨基-6-(4-甲氧基苯基)哒嗪

参考文献

Gavande, Navnath; Johnston, Graham A. R.; Hanrahan, Jane R.; Chebib, Mary
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4131 - 4136

5469-69-23-氨基-6-氯哒嗪

446273-59-23-氨基-4-溴-6-氯哒嗪

参考文献

WO2014/9305 A1, ;

Page/Page column 29 ;

71-23-8丙醇+

5469-69-23-氨基-6-氯哒嗪

90008-50-76-丙氧基哒嗪-3-胺

参考文献

Harrison, P. W.; Barlin, G. B.; Davies, L. P.; Ireland, S. J.; Matyus, P.; Wong, M. G.
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 9 p. 651 - 662