6-氯-9-乙基-9H-嘌呤合成路线 （共 13 条）
反应条件
in methanol T=50°C; 3 h;
参考文献
Young, Rodney C.; Jones, Martin; Milliner, Kevin J.; Rana, Kishore K.; Ward, John G.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2073 - 2080
参考文献
Montgomery; Temple
Journal of the American Chemical Society, 1957 , vol. 79, p. 5238,5241
反应条件
potassium carbonate in ethanol; dichloromethane; dimethyl sulfoxide
参考文献
Pharmacia and Upjohn S.p.A.
Patent: US5965563 A1, 1999 ;
反应条件
potassium carbonate; β-cyclodextrin in water
T=20°C; 1 h; regioselective reaction;
参考文献
Zhang, Qian; Cheng, Gang; Huang, Yong-Zhen; Qu, Gui-Rong; Niu, Hong-Ying; Guo, Hai-Ming
Tetrahedron, 2012 , vol. 68, # 38 p. 7822 - 7826
参考文献
Lambertucci, Catia; Antonini, Ippolito; Buccioni, Michela; Dal Ben, Diego; Kachare, Dhuldeo D.; Volpini, Rosaria; Klotz, Karl-Norbert; Cristalli, Gloria
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 7 p. 2812 - 2822
反应条件
tetrachloromethane; n-Pentyl nitrite
12 h; Heating;
参考文献
Nair, Vasu; Richardson, Stephen G.
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 3969 - 3974
反应条件
1: 40 percent / Sodium hydride / dimethylformamide
2: 68.1 percent / Carbon tetrachloride, n-pentyl nitrite / 12 h / Heating
View Scheme
参考文献
Nair, Vasu; Richardson, Stephen G.
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 3969 - 3974
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
16 h; Ambient temperature;
参考文献
Toyota; Katagiri; Kaneko
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 4 p. 1039 - 1041
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
10 h; Ambient temperature;
参考文献
Toyota; Katagiri; Kaneko
Synthetic Communications, 1993 , vol. 23, # 9 p. 1295 - 1305
反应条件
1: ethanol
2: aq. NaOH solution
View Scheme
参考文献
Montgomery; Temple
Journal of the American Chemical Society, 1957 , vol. 79, p. 5238,5241
