N-(3-溴丙基)苯二胺合成路线 （共 93 条）
参考文献
Putochin
Chemische Berichte, 1926 , vol. 59, p. 627
Chem. Zentralbl., 1928 , vol. 99, # I p. 318
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 3.5 h;
参考文献
Mountford, Simon J.; Campi, Eva M.; Robinson, Andrea J.; Hearn, Milton T.W.
Tetrahedron, 2011 , vol. 67, # 2 p. 471 - 485
反应条件
hydrazine hydrate
Multistep reaction;
参考文献
He, Xiao Shu; Woodruff, Kristine; Brodbeck, Robbin
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2399 - 2402
反应条件
potassium fluoride in acetonitrile
2 h; Heating;
参考文献
Samejima; Takeda; Kawase; Okada; Kyogoku
Chemical and pharmaceutical bulletin, 1984 , vol. 32, # 9 p. 3428 - 3435
反应条件
hydrazine hydrate; sodium amide in anhydrous xylene; ethanol; ethyl acetate
参考文献
Smith Kline and French Laboratories Limited
Patent: US4668671 A1, 1987 ;
US 4668671 A
反应条件
in N,N-dimethyl-formamide
Heating;
参考文献
Bremner, John B.; Browne, Elaine J.; Gunawardana, Indrani W. K.
Australian Journal of Chemistry, 1984 , vol. 37, # 1 p. 129 - 141
反应条件
1.1: NaH / dimethylformamide
1.2: KI / dimethylformamide / 16 h / Heating
2.1: NBS; Me2C(CN)-N=N-C(CN)Me2 / CCl4 / Heating; UV-irradiation
View Scheme
参考文献
Otzen, Thomas; Wempe, Ellen G.; Kunz, Brigitte; Bartels, Rainer; Lehwark-Yvetot, Gudrun; Haensel, Wolfram; Schaper, Klaus-Juergen; Seydel, Joachim K.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 240 - 253
反应条件
1: p-cresol With sodium hydride in N,N-dimethyl-formamide
2: 2-(3-bromopropyl)-1H-isoindole-1,3(2H)-dione With potassium iodide in N,N-dimethyl-formamide
16 h; Heating;
参考文献
Otzen, Thomas; Wempe, Ellen G.; Kunz, Brigitte; Bartels, Rainer; Lehwark-Yvetot, Gudrun; Haensel, Wolfram; Schaper, Klaus-Juergen; Seydel, Joachim K.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 240 - 253
反应条件
[Ni0(1,5-cyclooctadiene)2]; zinc; (4-Cl)-H-PyBox in N,N-dimethyl acetamide
T=25°C; 16 h; Inert atmosphere;
参考文献
Yu, Xiaolong; Yang, Tao; Wang, Shulin; Xu, Hailiang; Gong, Hegui
Organic Letters, 2011 , vol. 13, # 8 p. 2138 - 2141
反应条件
[Ni0(1,5-cyclooctadiene)2]; zinc; (S)-sBu-Pybox in N,N-dimethyl acetamide
T=25°C; 12 h; Inert atmosphere;
参考文献
Yu, Xiaolong; Yang, Tao; Wang, Shulin; Xu, Hailiang; Gong, Hegui
Organic Letters, 2011 , vol. 13, # 8 p. 2138 - 2141
