2-(3-碘丙基)-1H-异吲哚-1,3(2H)-二酮合成路线 （共 22 条）
反应条件
1: 0.78 g / Na2CO3 / CCl4 / 24 h / Heating
2: NaI / acetone / 20 h / Heating
View Scheme
参考文献
Prabhakaran; Woo; Yorgey; Gould
Journal of the American Chemical Society, 1988 , vol. 110, # 17 p. 5785 - 5791
反应条件
1: 51 percent / hexadecyltri-n-butyl phosphonium bromide / toluene / 3 h / 100 °C
2: 84 percent / NaI / acetone / 12 h / Heating
View Scheme
参考文献
Martinkus; Tann; Gould
Tetrahedron, 1983 , vol. 39, # 21 p. 3493 - 3505
反应条件
1: triethylamine / toluene / 2.5 h / |Inert atmosphere; |Schlenk technique; |Reflux; |Dean-Stark
2: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 4 h / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Levin, Vitalij V.; Zemtsov, Artem A.; Struchkova, Marina I.; Dilman, Alexander D.
Organic Letters, 2013 , vol. 15, # 4 p. 917 - 919
反应条件
1: K2CO3, n-Bu4NBr / acetone / 24 h / Ambient temperature
2: NaI / acetone / Ambient temperature
View Scheme
参考文献
Ha, Deok-Chan; Yun, Chang-Soo; Yu, Eunsun
Tetrahedron Letters, 1996 , vol. 37, # 15 p. 2577 - 2580
参考文献
Fraenkel
Chemische Berichte, 1897 , vol. 30, p. 2506
参考文献
Fraenkel
Chemische Berichte, 1897 , vol. 30, p. 2506
反应条件
1-methyl-1H-imidazole; tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=80°C; Negishi cross-coupling; 14 h;
参考文献
Zhou, Jianrong; Fu, Gregory C.
Journal of the American Chemical Society, 2003 , vol. 125, # 41 p. 12527 - 12530
参考文献
v. Braun; Pinkernelle
Chemische Berichte, 1934 , vol. 67, p. 1056,1220
反应条件
benzenesulphonyl azide; 1,1,1,2,2,2-hexabutyl-distannane; t-BuON=NOt-Bu in benzene
T=0°C; 8 h; Heating;
参考文献
Ollivier; Renaud
Journal of the American Chemical Society, 2001 , vol. 123, # 20 p. 4717 - 4727
反应条件
2: palladium; methanol / Hydrogenation
View Scheme
参考文献
v. Braun; Pinkernelle
Chemische Berichte, 1934 , vol. 67, p. 1056,1220
