1: 3-methyl-N,N-diisopropylbenzamide With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-50 - 20°C; Inert atmosphere; 3: With hydrogenchloride; acetic acid in water 24 h; RefluxInert atmosphere;

triethylamine in toluene T=20°C; 24 h; Inert atmosphere;

bis(acetylacetonate)nickel(II) in tetrahydrofuran T=20°C; 20 h;

1: meta-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C; 5 h; Inert atmosphere; 2: diisopropylamine in dichloromethane T=20°C; 4 h; Inert atmosphere;

bis(acetylacetonate)nickel(II); isopropylmagnesium chloride in tetrahydrofuran T=20°C; 20 h;

1: 1.) BuLi / 1) THF, -70 deg C, 30 min; 2) THF, room temperature, 1 h 2: 96 percent / sodium perborate tetrahydrate / acetic acid / 3 h / 50 °C 3: 1.) BuLi / 1) hexane, THF, -70 deg C, 30 min; 2) THF, hexane, -70 deg C --> room temperature 2 h 4: 5 percent Chromat. / Ni(acac)2 / tetrahydrofuran; diethyl ether / 24 h / 40 °C View Scheme

1: 96 percent / sodium perborate tetrahydrate / acetic acid / 3 h / 50 °C 2: 1.) BuLi / 1) hexane, THF, -70 deg C, 30 min; 2) THF, hexane, -70 deg C --> room temperature 2 h 3: 5 percent Chromat. / Ni(acac)2 / tetrahydrofuran; diethyl ether / 24 h / 40 °C View Scheme

1: 1.) BuLi / 1) hexane, THF, -70 deg C, 30 min; 2) THF, hexane, -70 deg C --> room temperature 2 h 2: 5 percent Chromat. / Ni(acac)2 / tetrahydrofuran; diethyl ether / 24 h / 40 °C View Scheme