2-苯氨基-3-硝基苯甲酸合成路线 （共 8 条）
反应条件
copper diacetate; potassium carbonate T=160°C; Ullmann Condensation; 1 h; Inert atmosphere;
参考文献
EP1940965 B1, ;
Paragraph 0105-0106 ;
反应条件
n-ethyl morpholine; copper; copper(l) chloride in various solvent(s) T=70°C; 15 h;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 5 p. 843 - 851
参考文献
Journal of the American Chemical Society, , vol. 45, p. 1914
反应条件
sodium tetrahydroborate; sodium ethanolate in ethanol 1 h; Heating;
参考文献
Rewcastle; Denny; Baguley
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 843 - 851
反应条件
1.1: sodium tetrahydroborate; sodium ethanolate / ethanol / 24 h / 65 °C / |Inert atmosphere
2.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 3 h / 20 °C / |Inert atmosphere
2.2: 2 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Borrero, Nicholas V.; Bai, Fang; Perez, Cristian; Duong, Benjamin Q.; Rocca, James R.; Jin, Shouguang; Huigens Iii, Robert W.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 6 p. 881 - 886
反应条件
trichlorophosphate
T=140°C; 1 h; Inert atmosphere;
参考文献
Almac Sciences (Scotland) Limited; RAMAGE, Robert; MALTMAN, Beatrice; COTTON, Graham; COUTURIER, Sarah, Claire, Monique; MCMORDIE, Robert, Austin, Simms
Patent: EP1940965 B1, 2014 ;
Location in patent: Paragraph 0107-0108 ;
反应条件
sulfuric acid
T=100°C;
参考文献
Goldberg; Kelly
Journal of the Chemical Society, 1946 , p. 102,107
反应条件
1: sodium tetrahydroborate; sodium ethanolate / ethanol / 24 h / 65 °C / |Inert atmosphere
2: thionyl chloride / toluene / 4 h / 65 °C / |Inert atmosphere
3: ammonia / water; dichloromethane / 20 °C / |Inert atmosphere
View Scheme
参考文献
Borrero, Nicholas V.; Bai, Fang; Perez, Cristian; Duong, Benjamin Q.; Rocca, James R.; Jin, Shouguang; Huigens Iii, Robert W.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 6 p. 881 - 886
