1-(2-甲基-2-硝基-丙基)-4-硝基-苯合成路线 （共 21 条）
反应条件
in water
T=100°C; Alkylation; 0.0666667 h; Irradiation;
参考文献
Vanelle, Patrice; Gellis, Armand; Kaafarani, Mustapha; Maldonado, Jose; Crozet, Michel P.
Tetrahedron Letters, 1999 , vol. 40, # 23 p. 4343 - 4346
反应条件
1-isopropyl-4-nitrobenzene; lithium in ethanol
T=12 - 13°C; effect of ultrasonic waves on ratio of C/O alkylation; Product distributionMechanism;
参考文献
Dickens; Luch
Tetrahedron Letters, 1991 , vol. 32, # 36 p. 4709 - 4712
反应条件
in dimethyl sulfoxide
T=25°C; 2 h; Rate constant;
参考文献
Katritzky, Alan R.; Kashmiri, M. Akram; Ville, George Z. de; Patel, Ranjan C.
Journal of the American Chemical Society, 1983 , vol. 105, # 1 p. 90 - 96
反应条件
in ethanol
T=15°C; 7 h;
参考文献
Einhorn; Dickens; Luche
Tetrahedron Letters, 1990 , vol. 31, # 29 p. 4129 - 4130
参考文献
Huber, Didier; Andermann, Guy; Lecrerc, Gerard
Tetrahedron Letters, 1988 , vol. 29, # 6 p. 635 - 638
参考文献
Hass; Berry; Bender
Journal of the American Chemical Society, 1949 , vol. 71, p. 2290
反应条件
1: 48 percent / Zn, aq. HCl / ethanol; H2O / Heating
2: 37 percent / NaI, thallium trichloride / H2O / 1 h / Heating; pH 4.0
View Scheme
参考文献
Rashidbaigi; Ruoho
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 3 p. 305 - 307
反应条件
1: 1.) H2, 2.) HCl / 1.) 10percent Pd/C / 1.) ethanol, 8 h, reflux
2: 82 percent / NaNO2, 37percent HCl / methanol; H2O / 1.) 5 deg C - room temp., 2.) 3 h, reflux
View Scheme
参考文献
Leclerc; Decker; Schwartz
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 9 p. 1357 - 1367
反应条件
hydrogen; palladium 10 on activated carbon in methanol
P=760.051 Torr;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/52078 A1, 2009 ;
Location in patent: Page/Page column 79 ;
WO 2009/052078 A1
反应条件
sodium tetrahydroborate; copper diacetate in methanol; diethyl ether
Ambient temperature;
参考文献
Cowan, J. A.
Tetrahedron Letters, 1986 , vol. 27, # 10 p. 1205 - 1208
