1-(2-甲基-2-硝基-丙基)-4-硝基-苯合成路线 （共 21 条）
反应条件
tetra(n-butyl)ammonium hydroxide in dichloromethane; water 36 h;
参考文献
Crozet, Michel P.; Vanelle, Patrice
Tetrahedron Letters, 1985 , vol. 26, # 3 p. 323 - 326
反应条件
1: 1.) H2, 2.) HCl / 1.) 10percent Pd/C / 1.) ethanol, 8 h, reflux 2: 1.) NaNO2, 37percent HCl, 2.) H3PO4 / 1.) MeOH, 3 h, reflux, water View Scheme
参考文献
Leclerc; Decker; Schwartz
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 9 p. 1357 - 1367
反应条件
ethanol; sodium
12 h; Heating;
参考文献
Leclerc; Decker; Schwartz
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 9 p. 1357 - 1367
反应条件
in N,N-dimethyl-formamide
T=-16°C; Alkylation; 35 h;
参考文献
Vanelle, Patrice; Gellis, Armand; Kaafarani, Mustapha; Maldonado, Jose; Crozet, Michel P.
Tetrahedron Letters, 1999 , vol. 40, # 23 p. 4343 - 4346
反应条件
N,N-di-tert-butylnitroxide in acetonitrile
T=20°C; Substitution; 1 h;
参考文献
Costentin, Cyrille; Hapiot, Philippe; Medebielle, Maurice; Saveant, Jean-Michel
Journal of the American Chemical Society, 2000 , vol. 122, # 23 p. 5623 - 5635
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
Hass-Bender/Henry reaction;
参考文献
Klein, Thomas A.; Schkeryantz, Jeffrey M.
Tetrahedron Letters, 2005 , vol. 46, # 27 p. 4535 - 4538
反应条件
1: aq. H2O2 / acetic acid
2: LiOEt / dimethylformamide / Irradiation
View Scheme
参考文献
Russell,G.A.; Pecoraro,J.M.
Journal of the American Chemical Society, 1979 , vol. 101, p. 3331 - 3334
反应条件
1: Na / ethanol
2: aq. H2O2 / acetic acid
3: LiOEt / dimethylformamide / Irradiation
View Scheme
参考文献
Russell,G.A.; Pecoraro,J.M.
Journal of the American Chemical Society, 1979 , vol. 101, p. 3331 - 3334
反应条件
lithium ethanolate in N,N-dimethyl-formamide
Irradiation;
参考文献
Russell,G.A.; Pecoraro,J.M.
Journal of the American Chemical Society, 1979 , vol. 101, p. 3331 - 3334
反应条件
sodium hydride
1.) CH3OH, 2.) DMSO, 80 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Kashmiri, M. Akram; Ville, George Z. de; Patel, Ranjan C.
Journal of the American Chemical Society, 1983 , vol. 105, # 1 p. 90 - 96
