1-溴-2-(氯甲基)-4,5-二甲氧基苯合成路线 （共 10 条）
反应条件
1: ethanol 2: ethanolic KOH-solution View Scheme
参考文献
Journal of the American Chemical Society, , vol. 59, p. 1541,1545
参考文献
Small; Turnbull
Journal of the American Chemical Society, 1937 , vol. 59, p. 1541,1545
参考文献
Ito; Tanaka
Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 9 p. 2108 - 2112
反应条件
pyridine; thionyl chloride in chloroform
T=0 - 20°C;
参考文献
Syntrix Biosystems, Inc.
Patent: US2010/210593 A1, 2010 ;
Location in patent: Page/Page column 45 ;
US 20100210593 A1
反应条件
hydrogenchloride; acetic acid
T=50°C; 17 h;
参考文献
Yamato, Takehiko; Sakaue, Naozumi; Komine, Masayasu; Nagano, Yoshiaki
Journal of Chemical Research, Miniprint, 1997 , # 7 p. 1708 - 1735
反应条件
1: 74 percent / NaBH4 / methanol; CHCl3 / 1 h / 0 °C
2: 82 percent / NCS; Me2S / CH2Cl2 / -25 - 0 °C
View Scheme
参考文献
Olivera, Roberto; SanMartin, Raul; Dominguez, Esther; Solans, Xabier; Urtiaga, Miren Karmele; Arriortua, Maria Isabel
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6398 - 6411
反应条件
1: 89 percent / Br2 / CHCl3 / 6 h / 60 °C
2: 74 percent / NaBH4 / methanol; CHCl3 / 1 h / 0 °C
3: 82 percent / NCS; Me2S / CH2Cl2 / -25 - 0 °C
View Scheme
参考文献
Olivera, Roberto; SanMartin, Raul; Dominguez, Esther; Solans, Xabier; Urtiaga, Miren Karmele; Arriortua, Maria Isabel
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6398 - 6411
反应条件
1: 73 percent / NaH / dimethylformamide; tetrahydrofuran / 5 h / 80 °C
2: 26 percent / P2O5; POCl3 / 2 h / Heating
3: 99 percent / Rose Bengal; O2 / methanol; CH2Cl2 / 0.25 h / 18 °C / UV-irradiation
4: 17 percent / LiAlH4 / tetrahydrofuran / 20 h / Heating
5: 71 percent / NaOAc; pyridinium chlorochromate / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Wada, Yasuhiro; Kaga, Harumi; Uchiito, Shiho; Kumazawa, Eri; Tomiki, Miho; Onozaki, Yu; Kurono, Nobuhito; Tokuda, Masao; Ohkuma, Takeshi; Orito, Kazuhiko
Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7301 - 7306
反应条件
1: 72 percent / 50percent NaOH / TEBAC / benzene / 8 h
2: OH(-)
3: OH-
View Scheme
参考文献
Lera, Angel Rodrigues de; Suau, Rafael; Castedo, Luis
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 313 - 319
反应条件
1: 60 percent / methylmagnesium iodide / diethyl ether / 3 h / Heating
2: 72 percent / H2 / 10percent Pd/C / methanol / 4 h / Ambient temperature
View Scheme
参考文献
Yamato, Takehiko; Sakaue, Naozumi; Komine, Masayasu; Nagano, Yoshiaki
Journal of Chemical Research, Miniprint, 1997 , # 7 p. 1708 - 1735
