(1H-苯并咪唑-2-基硫代)乙酸乙酯合成路线 (共 20 条)
反应条件
hydrazine hydrate in ethanol 5 h; Heating;
参考文献
Ahluwalia, V K; Tyagi, Renu; Khurana, Anju
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 12 p. 1097 - 1100
反应条件
ethylpolyphosphate in N,N-dimethyl-formamide
参考文献
Ogura,H. et al.
Chemical and Pharmaceutical Bulletin, 1968 , vol. 16, # 11 p. 2167 - 2171
反应条件
potassium carbonate
T=61 - 62°C; 0.0583333 h; microwave irradiation;
参考文献
Desai, Krunal G.; Desai, Kishor R.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8271 - 8279
反应条件
potassium carbonate in ethanol
Heating;
参考文献
Ram; Wise; Townsend
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1269 - 1274
反应条件
potassium carbonate in ethanol
6 h; Heating / reflux;
参考文献
OMEROS CORPORATION
Patent: WO2009/143178 A2, 2009 ;
Location in patent: Page/Page column 37-38 ;
WO 2009/143178 A2
参考文献
Graber, David R.; Morge, Raymond A.; Sih, John C.
Journal of Organic Chemistry, 1987 , vol. 52, # 20 p. 4620 - 4622
反应条件
[Cu(I)(CH3CN)4]PF6 in dichloromethane
Ambient temperature;
参考文献
Calo, Vincenzo; Nacci, Angelo; Fiandanese, Vito; Volpe, Angela
Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3289 - 3290
反应条件
1: sodium hydroxide / ethanol; H2O / 2.5 h / Heating
2: m-chloroperbenzoic acid / CHCl3 / 0.17 h / 0 - 5 °C
3: aq. ethanol / 25 °C
View Scheme
参考文献
Graber, David R.; Morge, Raymond A.; Sih, John C.
Journal of Organic Chemistry, 1987 , vol. 52, # 20 p. 4620 - 4622
反应条件
1: m-chloroperbenzoic acid / CHCl3 / 0.17 h / 0 - 5 °C
2: aq. ethanol / 25 °C
3: m-chloroperbenzoic acid / CHCl3 / 0.17 h / 0 - 5 °C
4: aq. ethanol / 25 °C
View Scheme
参考文献
Graber, David R.; Morge, Raymond A.; Sih, John C.
Journal of Organic Chemistry, 1987 , vol. 52, # 20 p. 4620 - 4622
反应条件
1: m-chloroperbenzoic acid / CHCl3 / 0.17 h / 0 - 5 °C
2: aq. ethanol / 25 °C
3: m-chloroperbenzoic acid / CHCl3 / 0.17 h / 0 - 5 °C
4: aq. ethanol / 25 °C
View Scheme
参考文献
Graber, David R.; Morge, Raymond A.; Sih, John C.
Journal of Organic Chemistry, 1987 , vol. 52, # 20 p. 4620 - 4622