3-溴-4-氧代戊酸乙酯合成路线 （共 11 条）
反应条件
1: 19 percent / ethanol / 12 h / Heating 2: 48 percent / 1 N NaOH / ethanol; H2O / 0.5 h / Ambient temperature View Scheme
参考文献
Abignente; Arena; Luraschi; Saturnino; Marmo; Russo; Magliulo
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 2 p. 119 - 130
反应条件
1: ethanol View Scheme
参考文献
Burger; Ullyot
Journal of Organic Chemistry, 1947 , vol. 12, p. 342,351
参考文献
Hara; Fujise
Pharmaceutical Bulletin, 1954 , vol. 2, p. 156
反应条件
1: 23 percent / ethanol / 6 h / Heating 2: 56 percent / 1 N NaOH / ethanol; H2O / 0.5 h / Ambient temperature View Scheme
参考文献
Abignente; Arena; Luraschi; Saturnino; Marmo; Russo; Magliulo
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 2 p. 119 - 130
反应条件
bromine in diethyl ether
参考文献
ABBVIE INC.; Cusack, Kevin P.; Gordon, Thomas D.; Hoemann, Michael Z.; Ihle, David C.; Li, Bin; Lo Schiavo, Gloria Y.; Somal, Gagandeep K.; Friedman, Michael; Hayes, Martin E.; Bakker, Wouter Iwema
Patent: US2014/179676 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: 35 g / H2SO4 / 20 h / Heating
2: 33 g / bromine / diethyl ether
View Scheme
参考文献
Joshi, U. R.; Limaye, P. A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 12 p. 1122
反应条件
hydrogen bromide; bromine; acetic acid in chloroform
1.) 50 deg C, 0.5 h, 2.) reflux, 1 h; Further byproducts given;
参考文献
Manny, Anthony J.; Kjelleberg, Staffan; Kumar, Naresh; De Nys, Rocky; Read, Roger W.; Steinberg, Peter
Tetrahedron, 1997 , vol. 53, # 46 p. 15813 - 15826
反应条件
hydrogen bromide; bromine; acetic acid in chloroform
1.) 50 deg C, 0.5 h, 2.) reflux, 1 h; Further byproducts given;
参考文献
Manny, Anthony J.; Kjelleberg, Staffan; Kumar, Naresh; De Nys, Rocky; Read, Roger W.; Steinberg, Peter
Tetrahedron, 1997 , vol. 53, # 46 p. 15813 - 15826
反应条件
hydrogen bromide; bromine; acetic acid in chloroform
1.) 50 deg C, 0.5 h, 2.) reflux, 1 h; various reactants ratio; Product distribution;
参考文献
Manny, Anthony J.; Kjelleberg, Staffan; Kumar, Naresh; De Nys, Rocky; Read, Roger W.; Steinberg, Peter
Tetrahedron, 1997 , vol. 53, # 46 p. 15813 - 15826
反应条件
hydrogen bromide; bromine; acetic acid in chloroform
1.) 50 deg C, 0.5 h, 2.) reflux, 1 h; various reactants ratio; Product distribution;
参考文献
Manny, Anthony J.; Kjelleberg, Staffan; Kumar, Naresh; De Nys, Rocky; Read, Roger W.; Steinberg, Peter
Tetrahedron, 1997 , vol. 53, # 46 p. 15813 - 15826
