3-二甲基氨基-1-(噻吩基)-1-丙酮盐酸盐合成路线 （共 22 条）
反应条件
hydrogenchloride in ethanol 24 h; Heating;
参考文献
Deeter, Jack; Frazier, Jeff; Staten, Gilbert; Staszak, Mike; Weigel, Leland
Tetrahedron Letters, 1990 , vol. 31, # 45 p. 7101 - 7104
反应条件
hydrogenchloride in isopropyl alcohol
参考文献
Knott
Journal of the Chemical Society, 1947 , p. 1196,1200
反应条件
triethylamine in ethanol 2 h; Heating;
参考文献
Eichinger; Nussbaumer
Synthesis, 1991 , # 8 p. 663 - 664
反应条件
potassium hydroxide; hydrazine hydrate in various solvent(s) 1) 140 deg C, 4 h; 2) 230 deg C;
参考文献
Mochalov, S.S.; Abdel'razek, F.M.; Surikova, T.P.; Shabarov, Yu.S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , vol. 16, # 4 p. 339 - 344
Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 4 p. 455 - 460
反应条件
sodium tetrahydroborate; sodium hydroxide in methanol; water T=35 - 40°C; 2 h;
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; TRIVEDI, Archana; KHARBANDA, Manlta; DUBEY, Shailendra; SINGLA, Sandeep; YOGIRAJ, Mansukhlal, Bodheka; VIR, Dharam
Patent: WO2011/33366 A2, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
1: LiAlH4, (2R,3S)-(+)-4-dimethylamino-1,2-diphenyl-3-methyl-2-butanol / tetrahydrofuran; toluene / 16 h / -70 °C 2: 1) NaH / 1) DMSO, 25 deg C, 25 min 2) 48-72 h, 45-50 deg C 3: 1) ClCO2CH2CCl3, Et3N, HCl 2) Zn-dust, 2.5percent formic acid / 1) toluene, 30 min, 25 deg C 2) DMF View Scheme
参考文献
Deeter, Jack; Frazier, Jeff; Staten, Gilbert; Staszak, Mike; Weigel, Leland
Tetrahedron Letters, 1990 , vol. 31, # 45 p. 7101 - 7104
反应条件
1: LiAlH4, (2R,3S)-(+)-4-dimethylamino-1,2-diphenyl-3-methyl-2-butanol / tetrahydrofuran; toluene / 16 h / -70 °C 2: 1) NaH / 1) DMSO, 25 deg C, 25 min 2) 48-72 h, 45-50 deg C 3: 1) ClCO2CH2CCl3, Et3N, HCl 2) Zn-dust, 2.5percent formic acid / 1) toluene, 30 min, 25 deg C 2) DMF View Scheme
参考文献
Deeter, Jack; Frazier, Jeff; Staten, Gilbert; Staszak, Mike; Weigel, Leland
Tetrahedron Letters, 1990 , vol. 31, # 45 p. 7101 - 7104
反应条件
1.1: sodium hydroxide; sodium tetrahydroborate / water; methanol / 2 h / 35 - 40 °C 2.1: sodium hydride / dimethyl sulfoxide / 20 °C 2.2: 48 - 50 °C 2.3: 5 h / 20 °C 3.1: sodium hydroxide / toluene; water / 20 - 45 °C / pH 11 - 12 View Scheme
反应条件
hydrogen; sodium hydrogencarbonate; (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine; [{Rh(μ-Cl)(1,5-cyclooctadiene)}2] in methanol; water T=30°C; P=75007.5 Torr; 20 h;
参考文献
Fujima, Yoshito; Ikunaka, Masaya; Inoue, Toru; Matsumoto, Jun
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 905 - 913
