1: 1-[2-(4-bromo-phenoxy)-ethyl]-pyrrolidine With tert.-butyl lithium in tetrahydrofuran T=-78°C; 1.5 h; Cooling with acetone-dry ice; 2: tri-isopropoxy-borane in tetrahydrofuran T=20°C; 15 h; 3: With hydrogenchloride in tetrahydrofuran T=20°C; 2 h;
The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland of Defence Evaluation Research Agency
Patent: US5861109 A1, 1999 ;
CH3CH2CH2CH2Li; HN(CH(CH3)2)2 in tetrahydrofuran treatment of pyridine deriv. with butyllithium and amine deriv. in THF at -78°C for 2 h, treatment with borate deriv. at -78°C for0.5 h, treatment with water and acetic acid at room temp.; chromy., NMR;
参考文献
Organic and Biomolecular Chemistry, , vol. 7, # 10 p. 2155 - 2161
