1: 2-hydroxy-5-nitro-pyridine With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20°C; 0.5 h;
2: ethyl iodide in N,N-dimethyl-formamide; mineral oil
T=20°C; 16 h;
参考文献
XCOVERY, INC.
Patent: WO2009/154769 A1, 2009 ;
Location in patent: Page/Page column 51 ;
WO 2009/154769 A1
1: trichlorophosphate; phosphorus pentachloride / 16 h / 60 °C
2: 1 h / 23 °C
3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 16 h / 23 °C
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